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公开(公告)号：US08136483B2
公开(公告)日：2012-03-20
申请号：US13165057
申请日：2011-06-21
IPC分类号： A01K29/00
CPC分类号： A61D19/027
摘要： A method and apparatus for safer and more effective deep trans-cervical intra-uterine artificial insemination (AI) is provided. Such a deep AI catheter causes minimal discomfort and risk of trauma, and does not require the services of a highly trained AI professional. First, a catheter is inserted into the cervical tract of the animal. A membrane, initially positioned inside a tube section of the catheter, is then extended from an opening in the tube and into the tract under pressure. The membrane extends into the tract without friction thereby reducing the discomfort and the risk of trauma or injury to the animal. When the membrane is fully extended into the tract, pressure causes the tip of the membrane to open thereby releasing the AI fluid and depositing the genetic material suspended in the fluid into the reproductive tract. In addition to AI and embryo transplant, other applications for the pathway include other therapeutic, diagnostic or procedures, such as introducing fluoroscopic cameras, instruments, and drug delivery.
摘要翻译： 提供了一种更安全，更有效的深层宫颈子宫内人工授精（AI）的方法和装置。 如此深入的AI导管引起最小的不适和创伤的风险，并且不需要训练有素的专业人员的服务。 首先，将导管插入动物的颈部管道。 最初定位在导管的管部分内的膜然后从管中的开口延伸并在压力下进入管道。 膜不会摩擦地延伸到管道中，从而减少对动物的不适和创伤或损伤的风险。 当膜完全延伸到管道中时，压力导致膜的顶端打开，从而释放AI流体并将悬浮在流体中的遗传物质沉积到生殖道中。 除AI和胚胎移植外，该途径的其他应用包括其他治疗，诊断或手术，如引入荧光镜照相机，仪器和药物递送。
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公开(公告)号：US07971553B2
公开(公告)日：2011-07-05
申请号：US12628012
申请日：2009-11-30
IPC分类号： A01K29/00
CPC分类号： A61D19/027
摘要： A method and apparatus for safer and more effective deep trans-cervical intra-uterine artificial insemination (AI) is provided. Such a deep AI catheter causes minimal discomfort and risk of trauma, and does not require the services of a highly trained AI professional. First, a catheter is inserted into the cervical tract of the animal. A membrane, initially positioned inside a tube section of the catheter, is then extended from an opening in the tube and into the tract under pressure. The membrane extends into the tract without friction thereby reducing the discomfort and the risk of trauma or injury to the animal. When the membrane is fully extended into the tract, pressure causes the tip of the membrane to open thereby releasing the AI fluid and depositing the genetic material suspended in the fluid into the reproductive tract. In addition to AI and embryo transplant, other applications for the pathway include other therapeutic, diagnostic or procedures, such as introducing fluoroscopic cameras, instruments, and drug delivery.
摘要翻译： 提供了一种更安全，更有效的深层宫颈子宫内人工授精（AI）的方法和装置。 如此深入的AI导管引起最小的不适和创伤的风险，并且不需要训练有素的专业人员的服务。 首先，将导管插入动物的颈部管道。 最初定位在导管的管部分内的膜然后从管中的开口延伸并在压力下进入管道。 膜不会摩擦地延伸到管道中，从而减少对动物的不适和创伤或损伤的风险。 当膜完全延伸到管道中时，压力导致膜的顶端打开，从而释放AI流体并将悬浮在流体中的遗传物质沉积到生殖道中。 除AI和胚胎移植外，该途径的其他应用包括其他治疗，诊断或手术，如引入荧光镜照相机，仪器和药物递送。
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公开(公告)号：US07647891B2
公开(公告)日：2010-01-19
申请号：US12045875
申请日：2008-03-11
IPC分类号： A01K29/00
CPC分类号： A61D19/027
摘要： A method and apparatus for safer and more effective deep trans-cervical intra-uterine artificial insemination (AI) is provided. Such a deep AI catheter causes minimal discomfort and risk of trauma, and does not require the services of a highly trained AI professional. First, a catheter is inserted into the cervical tract of the animal. A membrane, initially positioned inside a tube section of the catheter, is then extended from an opening in the tube and into the tract under pressure. The membrane extends into the tract without friction thereby reducing the discomfort and the risk of trauma or injury to the animal. When the membrane is fully extended into the tract, pressure causes the tip of the membrane to open thereby releasing the AI fluid and depositing the genetic material suspended in the fluid into the reproductive tract. In addition to AI and embryo transplant, other applications for the pathway include other therapeutic, diagnostic or procedures, such as introducing fluoroscopic cameras, instruments, and drug delivery.
摘要翻译： 提供了一种更安全，更有效的深层宫颈子宫内人工授精（AI）的方法和装置。 如此深入的AI导管引起最小的不适和创伤的风险，并且不需要训练有素的专业人员的服务。 首先，将导管插入动物的颈部管道。 最初定位在导管的管部分内的膜然后从管中的开口延伸并在压力下进入管道。 膜不会摩擦地延伸到管道中，从而减少对动物的不适和创伤或损伤的风险。 当膜完全延伸到管道中时，压力导致膜的尖端打开，从而释放AI流体并将悬浮在流体中的遗传物质沉积到生殖道中。 除AI和胚胎移植外，该途径的其他应用包括其他治疗，诊断或手术，如引入荧光镜照相机，仪器和药物递送。
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公开(公告)号：US06860235B2
公开(公告)日：2005-03-01
申请号：US10693661
申请日：2003-10-24
CPC分类号： A61D19/027
摘要： A method and apparatus for safer and more effective deep trans-cervical intra-uterine artificial insemination (AI) is provided. Such a deep AI catheter causes minimal discomfort and risk of trauma, and does not require the services of a highly trained AI professional. First, a catheter is inserted into the cervical tract of the animal. A membrane, initially positioned inside a tube section of the catheter, is then extended from an opening in the tube and into the tract under pressure. The membrane extends into the tract without friction thereby reducing the discomfort and the risk of trauma or injury to the animal. When the membrane is fully extended into the tract, pressure causes the tip of the membrane to open thereby releasing the AI fluid and depositing the genetic material suspended in the fluid into the reproductive tract. Deployment of the membrane is facilitated by tapering its wall thickness towards its tip. In addition to AI and embryo transplant, other applications for the pathway include therapeutic, diagnostic, or other procedures such as introducing fluoroscopic cameras, instruments, and drug delivery.
摘要翻译： 提供了一种更安全，更有效的深层宫颈子宫内人工授精（AI）的方法和装置。 如此深入的AI导管引起最小的不适和创伤的风险，并且不需要训练有素的专业人员的服务。 首先，将导管插入动物的颈部管道。 最初定位在导管的管部分内的膜然后从管中的开口延伸并在压力下进入管道。 膜不会摩擦地延伸到管道中，从而减少对动物的不适和创伤或损伤的风险。 当膜完全延伸到管道中时，压力导致膜的顶端打开，从而释放AI流体并将悬浮在流体中的遗传物质沉积到生殖道中。 通过使其壁厚朝其尖端逐渐变细来促进膜的部署。 除了AI和胚胎移植之外，该途径的其他应用包括治疗，诊断或其他手术，例如引入荧光镜照相机，仪器和药物递送。
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公开(公告)号：US07343875B2
公开(公告)日：2008-03-18
申请号：US10693660
申请日：2003-10-24
IPC分类号： A01K29/00
CPC分类号： A61D19/027 , Y10S604/906
摘要： A method and apparatus for safer and more effective deep trans-cervical intra-uterine artificial insemination (AI) is provided. Such a deep AI catheter causes minimal discomfort and risk of trauma, and does not require the services of a highly trained AI professional. First, a catheter is inserted into the cervical tract of the animal. A membrane, initially positioned inside a tube section of the catheter, is then extended from an opening in the tube and into the tract under pressure. The membrane extends into the tract without friction thereby reducing the discomfort and the risk of trauma or injury to the animal. When the membrane is fully extended into the tract, pressure causes the tip of the membrane to open thereby releasing the AI fluid and depositing the genetic material suspended in the fluid into the reproductive tract. In addition to AI and embryo transplant, other applications for the pathway include other therapeutic, diagnostic or procedures, such as introducing fluoroscopic cameras, instruments, and drug delivery.
摘要翻译： 提供了一种更安全，更有效的深层宫颈子宫内人工授精（AI）的方法和装置。 如此深入的AI导管引起最小的不适和创伤的风险，并且不需要训练有素的专业人员的服务。 首先，将导管插入动物的颈部管道。 最初定位在导管的管部分内的膜然后从管中的开口延伸并在压力下进入管道。 膜不会摩擦地延伸到管道中，从而减少对动物的不适和创伤或损伤的风险。 当膜完全延伸到管道中时，压力导致膜的顶端打开，从而释放AI流体并将悬浮在流体中的遗传物质沉积到生殖道中。 除AI和胚胎移植外，该途径的其他应用包括其他治疗，诊断或手术，如引入荧光镜照相机，仪器和药物递送。
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公开(公告)号：US06526917B1
公开(公告)日：2003-03-04
申请号：US10161575
申请日：2002-05-31
IPC分类号： A01K2900
CPC分类号： A61D19/027 , Y10S604/906
摘要： A method and apparatus for safer and more effective deep trans-cervical intra-uterine artificial insemination (AI) is provided. Such a deep AI catheter causes minimal discomfort and risk of trauma, and does not require the services of a highly trained AI professional. First, a catheter is inserted into the cervical tract of the animal. A membrane, initially positioned inside a tube section of the catheter, is then extended from an opening in the tube and into the tract under pressure. The membrane extends into the tract without friction thereby reducing the discomfort and the risk of trauma or injury to the animal. When the membrane is fully extended into the tract, pressure causes the tip of the membrane to open thereby releasing the AI fluid and depositing the genetic material suspended in the fluid into the reproductive tract. In addition to AI and embryo transplant, other applications for the pathway include other therapeutic, diagnostic or procedures, such as introducing fluoroscopic cameras, instruments, and drug delivery.
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公开(公告)号：US20080154088A1
公开(公告)日：2008-06-26
申请号：US12045875
申请日：2008-03-11
CPC分类号： A61D19/027
摘要： A method and apparatus for safer and more effective deep trans-cervical intra-uterine artificial insemination (AI) is provided. Such a deep AI catheter causes minimal discomfort and risk of trauma, and does not require the services of a highly trained AI professional. First, a catheter is inserted into the cervical tract of the animal. A membrane, initially positioned inside a tube section of the catheter, is then extended from an opening in the tube and into the tract under pressure. The membrane extends into the tract without friction thereby reducing the discomfort and the risk of trauma or injury to the animal. When the membrane is fully extended into the tract, pressure causes the tip of the membrane to open thereby releasing the AI fluid and depositing the genetic material suspended in the fluid into the reproductive tract. In addition to AI and embryo transplant, other applications for the pathway include other therapeutic, diagnostic or procedures, such as introducing fluoroscopic cameras, instruments, and drug delivery.
摘要翻译： 提供了一种更安全，更有效的深层宫颈子宫内人工授精（AI）的方法和装置。 如此深入的AI导管引起最小的不适和创伤的风险，并且不需要训练有素的专业人员的服务。 首先，将导管插入动物的颈部管道。 最初定位在导管的管部分内的膜然后从管中的开口延伸并在压力下进入管道。 膜不会摩擦地延伸到管道中，从而减少对动物的不适和创伤或损伤的风险。 当膜完全延伸到管道中时，压力导致膜的顶端打开，从而释放AI流体并将悬浮在流体中的遗传物质沉积到生殖道中。 除AI和胚胎移植外，该途径的其他应用包括其他治疗，诊断或手术，如引入荧光镜照相机，仪器和药物递送。
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公开(公告)号：US06662750B2
公开(公告)日：2003-12-16
申请号：US10304524
申请日：2002-11-26
IPC分类号： A01K2900
CPC分类号： A61D19/027 , Y10S604/906
摘要： A method and apparatus for safer and more effective deep trans-cervical intra-uterine artificial insemination (AI) is provided. Such a deep AI catheter causes minimal discomfort and risk of trauma, and does not require the services of a highly trained AI professional. First, a catheter is inserted into the cervical tract of the animal. A membrane, initially positioned inside a tube section of the catheter, is then extended from an opening in the tube and into the tract under pressure. The membrane extends into the tract without friction thereby reducing the discomfort and the risk of trauma or injury to the animal. When the membrane is fully extended into the tract, pressure causes the tip of the membrane to open thereby releasing the AI fluid and depositing the genetic material suspended in the fluid into the reproductive tract. In addition to AI and embryo transplant, other applications for the pathway include other therapeutic, diagnostic or procedures, such as introducing fluoroscopic cameras, instruments, and drug delivery.
摘要翻译： 提供了一种更安全，更有效的深层宫颈子宫内人工授精（AI）的方法和装置。 如此深入的AI导管引起最小的不适和创伤的风险，并且不需要训练有素的专业人员的服务。 首先，将导管插入动物的颈部管道。 最初定位在导管的管部分内的膜然后从管中的开口延伸并在压力下进入管道。 膜不会摩擦地延伸到管道中，从而减少对动物的不适和创伤或损伤的风险。 当膜完全延伸到管道中时，压力导致膜的顶端打开，从而释放AI流体并将悬浮在流体中的遗传物质沉积到生殖道中。 除AI和胚胎移植外，该途径的其他应用包括其他治疗，诊断或手术，如引入荧光镜照相机，仪器和药物递送。
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公开(公告)号：US20110184415A1
公开(公告)日：2011-07-28
申请号：US13013669
申请日：2011-01-25
IPC分类号： A61B17/80
CPC分类号： A61B17/7059 , A61B17/8047 , A61B17/8052
摘要： A bone stabilization system is provided having a plate with a top and bottom surface and a hole therethrough extending along a longitudinal axis. An annular groove in the top surface encircles the axis and defines outer facing sides of a plurality of spring members integral to the plate. A plurality of slots define sides of the spring members the inward facing side of the spring members form the upper portion of the hole, which includes a first spherical portion. A fastener with a spherical portion on the fastener head extends into the hole with the spring members urged apart to allow the head to pass but restraining removal until the resistance provide by the spring members is overcome.
摘要翻译： 提供骨稳定系统，其具有具有顶表面和底表面的平板和沿着纵向轴线延伸穿过的孔。 顶表面中的环形槽围绕轴线并且限定与板成一体的多个弹簧构件的面向外侧。 多个槽限定弹簧构件的侧面，弹簧构件的向内侧形成孔的上部，其包括第一球形部分。 在紧固件头部上具有球形部分的紧固件延伸到孔中，弹簧构件被推开以允许头部通过，但是限制去除，直到克服了由弹簧构件提供的阻力。
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10.发明申请Methods of Treating Pulmonary Diseases and Disorders by Modulating Calcium/Calmodulin Dependent Protein Kinase II Activity 有权通过调节钙/钙调素依赖性蛋白激酶II活性治疗肺疾病和疾病的方法公开(公告)号：US20110152172A1
公开(公告)日：2011-06-23
申请号：US12820802
申请日：2010-06-22
IPC分类号： A61K38/00 , A61K31/4045 , A61K31/4709 , A61K31/496 , A61K31/454 , A61P11/06
CPC分类号： A61K31/18 , A61K31/4045 , A61K31/454 , A61K31/4709 , A61K31/496
摘要： Disclosed are methods of treating or preventing a pulmonary disease or disorder in a subject, the methods comprising administering an effective amount of an compound that inhibits Calmodulin Kinase II (CaMKII) activity, either directly or indirectly, thereby treating or preventing the pulmonary disease or disorder in the subject.
摘要翻译： 公开了治疗或预防受试者的肺部疾病或病症的方法，所述方法包括直接或间接施用有效量的抑制钙调蛋白激酶II（CaMKII）活性的化合物，从而治疗或预防肺部疾病或病症 在主题。
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