公开(公告)号：US09675637B2

公开(公告)日：2017-06-13

申请号：US10563683

申请日：2004-07-09

申请人： Mark T. Gladwin ,  Alan N. Schechter ,  David J. Lefer ,  Rakesh P. Patel ,  Christian J. Hunter ,  Gordon G. Power ,  Daniel B. Kim-Shapiro ,  Ryszard Pluta ,  Edward H. Oldfield ,  Richard O. Cannon, III

发明人： Mark T. Gladwin ,  Alan N. Schechter ,  David J. Lefer ,  Rakesh P. Patel ,  Christian J. Hunter ,  Gordon G. Power ,  Daniel B. Kim-Shapiro ,  Ryszard Pluta ,  Edward H. Oldfield ,  Richard O. Cannon, III

IPC分类号： A61K45/06 ,  A61K33/00

CPC分类号： A61K33/00 ,  A61K45/06 ,  A61K2300/00

摘要： It has been surprisingly discovered that administration of nitrite to subjects causes a reduction in blood pressure and an increase in blood flow to tissues. The effect is particularly beneficial, for example, to tissues in regions of low oxygen tension. This discovery provides useful treatments to regulate a subject's blood pressure and blood flow, for example, by the administration of nitrite salts. Provided herein are methods of administering a pharmaceutically-acceptable nitrite salt to a subject, for treating, preventing or ameliorating a condition selected from: (a) ischemia-reperfusion injury (e.g., hepatic or cardiac or brain ischemia-reperfusion injury); (b) pulmonary hypertension (e.g., neonatal pulmonary hypertension); or (c) cerebral artery vasospasm.

公开(公告)号：US20100247682A1

公开(公告)日：2010-09-30

申请号：US12748184

申请日：2010-03-26

申请人： Mark T. Gladwin ,  Alan N. Schechter ,  David J. Lefer ,  Rakesh P. Patel ,  Christian J. Hunter ,  Gordon G. Power ,  Daniel B. Kim-Shapiro ,  Ryszard Marek Pluta ,  Edward H. Oldfield ,  Richard O. Cannon, III

发明人： Mark T. Gladwin ,  Alan N. Schechter ,  David J. Lefer ,  Rakesh P. Patel ,  Christian J. Hunter ,  Gordon G. Power ,  Daniel B. Kim-Shapiro ,  Ryszard Marek Pluta ,  Edward H. Oldfield ,  Richard O. Cannon, III

IPC分类号： A61K33/00 ,  A61K31/198 ,  A61P9/00 ,  A61P11/00

CPC分类号： A61K33/00 ,  A61K45/06 ,  A61K2300/00

摘要： It has been surprisingly discovered that administration of nitrite to subjects causes a reduction in blood pressure and an increase in blood flow to tissues. The effect is particularly beneficial, for example, to tissues in regions of low oxygen tension. This discovery provides useful treatments to regulate a subject's blood pressure and blood flow, for example, by the administration of nitrite salts. Provided herein are methods of administering a pharmaceutically-acceptable nitrite salt to a subject, for treating, preventing or ameliorating a condition selected from: (a) ischemia-reperfusion injury (e.g., hepatic or cardiac or brain ischemia-reperfusion injury); (b) pulmonary hypertension (e.g., neonatal pulmonary hypertension); or (c) cerebral artery vasospasm.

摘要翻译： 令人惊讶地发现，向受试者施用亚硝酸盐导致血压降低和对组织的血流量的增加。 该效果特别有利于例如低氧张力区域中的组织。 该发现提供了有用的治疗方法来调节受试者的血压和血流量，例如通过施用亚硝酸盐。 本文提供了向受试者施用药学上可接受的亚硝酸盐，用于治疗，预防或改善选自以下的病症的方法：（a）缺血再灌注损伤（例如肝脏或心脏或脑缺血再灌注损伤）; （b）肺动脉高压（如新生儿肺动脉高压）; 或（c）大脑动脉血管痉挛。

公开(公告)号：US08927030B2

公开(公告)日：2015-01-06

申请号：US12748184

申请日：2010-03-26

申请人： Mark T. Gladwin ,  Alan N. Schechter ,  David J. Lefer ,  Rakesh P. Patel ,  Christian J. Hunter ,  Gordon G. Power ,  Daniel B. Kim-Shapiro ,  Ryszard Marek Pluta ,  Edward H. Oldfield ,  Richard O. Cannon, III

发明人： Mark T. Gladwin ,  Alan N. Schechter ,  David J. Lefer ,  Rakesh P. Patel ,  Christian J. Hunter ,  Gordon G. Power ,  Daniel B. Kim-Shapiro ,  Ryszard Marek Pluta ,  Edward H. Oldfield ,  Richard O. Cannon, III

IPC分类号： A01N59/00 ,  A61K33/00 ,  A01N37/12 ,  A01N37/44 ,  A61K45/06

CPC分类号： A61K33/00 ,  A61K45/06 ,  A61K2300/00

摘要： It has been surprisingly discovered that administration of nitrite to subjects causes a reduction in blood pressure and an increase in blood flow to tissues. The effect is particularly beneficial, for example, to tissues in regions of low oxygen tension. This discovery provides useful treatments to regulate a subject's blood pressure and blood flow, for example, by the administration of nitrite salts. Provided herein are methods of administering a pharmaceutically-acceptable nitrite salt to a subject, for treating, preventing or ameliorating a condition selected from: (a) ischemia-reperfusion injury (e.g., hepatic or cardiac or brain ischemia-reperfusion injury); (b) pulmonary hypertension (e.g., neonatal pulmonary hypertension); or (c) cerebral artery vasospasm.

摘要翻译： 令人惊讶地发现，向受试者施用亚硝酸盐导致血压降低和对组织的血流量的增加。 该效果特别有利于例如低氧张力区域中的组织。 该发现提供了有用的治疗方法来调节受试者的血压和血流量，例如通过施用亚硝酸盐。 本文提供了向受试者施用药学上可接受的亚硝酸盐，用于治疗，预防或改善选自以下的病症的方法：（a）缺血再灌注损伤（例如肝脏或心脏或脑缺血再灌注损伤）; （b）肺动脉高压（如新生儿肺动脉高压）; 或（c）大脑动脉血管痉挛。

公开(公告)号：US09387224B2

公开(公告)日：2016-07-12

申请号：US13407118

申请日：2012-02-28

申请人： Mark T. Gladwin ,  Alan N. Schechter ,  Christian J. Hunter ,  Gordon G. Power ,  Daniel B. Kim-Shapiro ,  Richard O. Cannon, III

发明人： Mark T. Gladwin ,  Alan N. Schechter ,  Christian J. Hunter ,  Gordon G. Power ,  Daniel B. Kim-Shapiro ,  Richard O. Cannon, III

IPC分类号： A01N59/00 ,  A61K33/00 ,  A01N37/12 ,  A01N37/44 ,  A61K45/06

CPC分类号： A61K33/00 ,  A61K45/06 ,  A61K2300/00

摘要： It has been surprisingly discovered that administration of nitrite to subjects causes a reduction in blood pressure and an increase in blood flow to tissues. The effect is particularly beneficial, for example, to tissues in regions of low oxygen tension. This discovery provides useful treatments to regulate a subject's blood pressure and blood flow, for example, by the administration of nitrite salts. Provided herein are methods of administering a pharmaceutically-acceptable nitrite salt to a subject, for treating, preventing or ameliorating a condition selected from: (a) ischemia-reperfusion injury (e.g., hepatic or cardiac or brain ischemia-reperfusion injury); (b) pulmonary hypertension (e.g., neonatal pulmonary hypertension); or (c) cerebral artery vasospasm.

摘要翻译： 令人惊讶地发现，向受试者施用亚硝酸盐导致血压降低和对组织的血流量的增加。 该效果特别有利于例如低氧张力区域中的组织。 该发现提供了有用的治疗方法来调节受试者的血压和血流量，例如通过施用亚硝酸盐。 本文提供了向受试者施用药学上可接受的亚硝酸盐，用于治疗，预防或改善选自以下的病症的方法：（a）缺血再灌注损伤（例如肝脏或心脏或脑缺血再灌注损伤）; （b）肺动脉高压（如新生儿肺动脉高压）; 或（c）大脑动脉血管痉挛。

公开(公告)号：US20120195983A1

公开(公告)日：2012-08-02

申请号：US13407118

申请日：2012-02-28

申请人： Mark T. Gladwin ,  Alan N. Schechter ,  Christian J. Hunter ,  Gordon G. Power ,  Daniel B. Kim-Shapiro ,  Richard O. Cannon, III

发明人： Mark T. Gladwin ,  Alan N. Schechter ,  Christian J. Hunter ,  Gordon G. Power ,  Daniel B. Kim-Shapiro ,  Richard O. Cannon, III

IPC分类号： A61K33/00 ,  A61P9/10 ,  A61P9/12

CPC分类号： A61K33/00 ,  A61K45/06 ,  A61K2300/00

摘要： It has been surprisingly discovered that administration of nitrite to subjects causes a reduction in blood pressure and an increase in blood flow to tissues. The effect is particularly beneficial, for example, to tissues in regions of low oxygen tension. This discovery provides useful treatments to regulate a subject's blood pressure and blood flow, for example, by the administration of nitrite salts. Provided herein are methods of administering a pharmaceutically-acceptable nitrite salt to a subject, for treating, preventing or ameliorating a condition selected from: (a) ischemia-reperfusion injury (e.g., hepatic or cardiac or brain ischemia-reperfusion injury); (b) pulmonary hypertension (e.g., neonatal pulmonary hypertension); or (c) cerebral artery vasospasm.

摘要翻译： 令人惊讶地发现，向受试者施用亚硝酸盐导致血压降低和对组织的血流量的增加。 该效果特别有利于例如低氧张力区域中的组织。 该发现提供了有用的治疗方法来调节受试者的血压和血流量，例如通过施用亚硝酸盐。 本文提供了向受试者施用药学上可接受的亚硝酸盐，用于治疗，预防或改善选自以下的病症的方法：（a）缺血再灌注损伤（例如肝脏或心脏或脑缺血再灌注损伤）; （b）肺动脉高压（如新生儿肺动脉高压）; 或（c）大脑动脉血管痉挛。

公开(公告)号：US5281519A

公开(公告)日：1994-01-25

申请号：US965513

申请日：1992-10-23

申请人： Alan N. Schechter ,  Shu-Zhen Huang ,  Griffin P. Rodgers

发明人： Alan N. Schechter ,  Shu-Zhen Huang ,  Griffin P. Rodgers

IPC分类号： C12Q1/68 ,  C12P19/34

CPC分类号： C12Q1/6883 ,  C12Q2600/156

摘要： A simple, rapid and reliable method for diagnosis of thalassemia is described. The method comprises amplification of the cDNA by polymerase chain reaction and determining the ratio between .alpha. and .beta. hemoglobin chain mRNAs.

摘要翻译： 描述了用于诊断地中海贫血的简单，快速和可靠的方法。 该方法包括通过聚合酶链反应扩增cDNA并确定（α）和（β）血红蛋白链mRNA之间的比例。