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公开(公告)号：US20100247682A1
公开(公告)日：2010-09-30
申请号：US12748184
申请日：2010-03-26
申请人： Mark T. Gladwin , Alan N. Schechter , David J. Lefer , Rakesh P. Patel , Christian J. Hunter , Gordon G. Power , Daniel B. Kim-Shapiro , Ryszard Marek Pluta , Edward H. Oldfield , Richard O. Cannon, III
发明人： Mark T. Gladwin , Alan N. Schechter , David J. Lefer , Rakesh P. Patel , Christian J. Hunter , Gordon G. Power , Daniel B. Kim-Shapiro , Ryszard Marek Pluta , Edward H. Oldfield , Richard O. Cannon, III
IPC分类号： A61K33/00 , A61K31/198 , A61P9/00 , A61P11/00
CPC分类号： A61K33/00 , A61K45/06 , A61K2300/00
摘要： It has been surprisingly discovered that administration of nitrite to subjects causes a reduction in blood pressure and an increase in blood flow to tissues. The effect is particularly beneficial, for example, to tissues in regions of low oxygen tension. This discovery provides useful treatments to regulate a subject's blood pressure and blood flow, for example, by the administration of nitrite salts. Provided herein are methods of administering a pharmaceutically-acceptable nitrite salt to a subject, for treating, preventing or ameliorating a condition selected from: (a) ischemia-reperfusion injury (e.g., hepatic or cardiac or brain ischemia-reperfusion injury); (b) pulmonary hypertension (e.g., neonatal pulmonary hypertension); or (c) cerebral artery vasospasm.
摘要翻译： 令人惊讶地发现，向受试者施用亚硝酸盐导致血压降低和对组织的血流量的增加。 该效果特别有利于例如低氧张力区域中的组织。 该发现提供了有用的治疗方法来调节受试者的血压和血流量，例如通过施用亚硝酸盐。 本文提供了向受试者施用药学上可接受的亚硝酸盐，用于治疗，预防或改善选自以下的病症的方法：（a）缺血再灌注损伤（例如肝脏或心脏或脑缺血再灌注损伤）; （b）肺动脉高压（如新生儿肺动脉高压）; 或（c）大脑动脉血管痉挛。
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公开(公告)号：US08927030B2
公开(公告)日：2015-01-06
申请号：US12748184
申请日：2010-03-26
申请人： Mark T. Gladwin , Alan N. Schechter , David J. Lefer , Rakesh P. Patel , Christian J. Hunter , Gordon G. Power , Daniel B. Kim-Shapiro , Ryszard Marek Pluta , Edward H. Oldfield , Richard O. Cannon, III
发明人： Mark T. Gladwin , Alan N. Schechter , David J. Lefer , Rakesh P. Patel , Christian J. Hunter , Gordon G. Power , Daniel B. Kim-Shapiro , Ryszard Marek Pluta , Edward H. Oldfield , Richard O. Cannon, III
CPC分类号： A61K33/00 , A61K45/06 , A61K2300/00
摘要： It has been surprisingly discovered that administration of nitrite to subjects causes a reduction in blood pressure and an increase in blood flow to tissues. The effect is particularly beneficial, for example, to tissues in regions of low oxygen tension. This discovery provides useful treatments to regulate a subject's blood pressure and blood flow, for example, by the administration of nitrite salts. Provided herein are methods of administering a pharmaceutically-acceptable nitrite salt to a subject, for treating, preventing or ameliorating a condition selected from: (a) ischemia-reperfusion injury (e.g., hepatic or cardiac or brain ischemia-reperfusion injury); (b) pulmonary hypertension (e.g., neonatal pulmonary hypertension); or (c) cerebral artery vasospasm.
摘要翻译： 令人惊讶地发现，向受试者施用亚硝酸盐导致血压降低和对组织的血流量的增加。 该效果特别有利于例如低氧张力区域中的组织。 该发现提供了有用的治疗方法来调节受试者的血压和血流量，例如通过施用亚硝酸盐。 本文提供了向受试者施用药学上可接受的亚硝酸盐，用于治疗，预防或改善选自以下的病症的方法：（a）缺血再灌注损伤（例如肝脏或心脏或脑缺血再灌注损伤）; （b）肺动脉高压（如新生儿肺动脉高压）; 或（c）大脑动脉血管痉挛。
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公开(公告)号：US09675637B2
公开(公告)日：2017-06-13
申请号：US10563683
申请日：2004-07-09
申请人： Mark T. Gladwin , Alan N. Schechter , David J. Lefer , Rakesh P. Patel , Christian J. Hunter , Gordon G. Power , Daniel B. Kim-Shapiro , Ryszard Pluta , Edward H. Oldfield , Richard O. Cannon, III
发明人： Mark T. Gladwin , Alan N. Schechter , David J. Lefer , Rakesh P. Patel , Christian J. Hunter , Gordon G. Power , Daniel B. Kim-Shapiro , Ryszard Pluta , Edward H. Oldfield , Richard O. Cannon, III
CPC分类号： A61K33/00 , A61K45/06 , A61K2300/00
摘要： It has been surprisingly discovered that administration of nitrite to subjects causes a reduction in blood pressure and an increase in blood flow to tissues. The effect is particularly beneficial, for example, to tissues in regions of low oxygen tension. This discovery provides useful treatments to regulate a subject's blood pressure and blood flow, for example, by the administration of nitrite salts. Provided herein are methods of administering a pharmaceutically-acceptable nitrite salt to a subject, for treating, preventing or ameliorating a condition selected from: (a) ischemia-reperfusion injury (e.g., hepatic or cardiac or brain ischemia-reperfusion injury); (b) pulmonary hypertension (e.g., neonatal pulmonary hypertension); or (c) cerebral artery vasospasm.
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公开(公告)号：US09387224B2
公开(公告)日：2016-07-12
申请号：US13407118
申请日：2012-02-28
申请人： Mark T. Gladwin , Alan N. Schechter , Christian J. Hunter , Gordon G. Power , Daniel B. Kim-Shapiro , Richard O. Cannon, III
发明人： Mark T. Gladwin , Alan N. Schechter , Christian J. Hunter , Gordon G. Power , Daniel B. Kim-Shapiro , Richard O. Cannon, III
CPC分类号： A61K33/00 , A61K45/06 , A61K2300/00
摘要： It has been surprisingly discovered that administration of nitrite to subjects causes a reduction in blood pressure and an increase in blood flow to tissues. The effect is particularly beneficial, for example, to tissues in regions of low oxygen tension. This discovery provides useful treatments to regulate a subject's blood pressure and blood flow, for example, by the administration of nitrite salts. Provided herein are methods of administering a pharmaceutically-acceptable nitrite salt to a subject, for treating, preventing or ameliorating a condition selected from: (a) ischemia-reperfusion injury (e.g., hepatic or cardiac or brain ischemia-reperfusion injury); (b) pulmonary hypertension (e.g., neonatal pulmonary hypertension); or (c) cerebral artery vasospasm.
摘要翻译： 令人惊讶地发现，向受试者施用亚硝酸盐导致血压降低和对组织的血流量的增加。 该效果特别有利于例如低氧张力区域中的组织。 该发现提供了有用的治疗方法来调节受试者的血压和血流量，例如通过施用亚硝酸盐。 本文提供了向受试者施用药学上可接受的亚硝酸盐，用于治疗，预防或改善选自以下的病症的方法：（a）缺血再灌注损伤（例如肝脏或心脏或脑缺血再灌注损伤）; （b）肺动脉高压（如新生儿肺动脉高压）; 或（c）大脑动脉血管痉挛。
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公开(公告)号：US20120195983A1
公开(公告)日：2012-08-02
申请号：US13407118
申请日：2012-02-28
申请人： Mark T. Gladwin , Alan N. Schechter , Christian J. Hunter , Gordon G. Power , Daniel B. Kim-Shapiro , Richard O. Cannon, III
发明人： Mark T. Gladwin , Alan N. Schechter , Christian J. Hunter , Gordon G. Power , Daniel B. Kim-Shapiro , Richard O. Cannon, III
CPC分类号： A61K33/00 , A61K45/06 , A61K2300/00
摘要： It has been surprisingly discovered that administration of nitrite to subjects causes a reduction in blood pressure and an increase in blood flow to tissues. The effect is particularly beneficial, for example, to tissues in regions of low oxygen tension. This discovery provides useful treatments to regulate a subject's blood pressure and blood flow, for example, by the administration of nitrite salts. Provided herein are methods of administering a pharmaceutically-acceptable nitrite salt to a subject, for treating, preventing or ameliorating a condition selected from: (a) ischemia-reperfusion injury (e.g., hepatic or cardiac or brain ischemia-reperfusion injury); (b) pulmonary hypertension (e.g., neonatal pulmonary hypertension); or (c) cerebral artery vasospasm.
摘要翻译： 令人惊讶地发现，向受试者施用亚硝酸盐导致血压降低和对组织的血流量的增加。 该效果特别有利于例如低氧张力区域中的组织。 该发现提供了有用的治疗方法来调节受试者的血压和血流量，例如通过施用亚硝酸盐。 本文提供了向受试者施用药学上可接受的亚硝酸盐，用于治疗，预防或改善选自以下的病症的方法：（a）缺血再灌注损伤（例如肝脏或心脏或脑缺血再灌注损伤）; （b）肺动脉高压（如新生儿肺动脉高压）; 或（c）大脑动脉血管痉挛。
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