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公开(公告)号：US12014281B2
公开(公告)日：2024-06-18
申请号：US16952667
申请日：2020-11-19
Applicant: Merative US L.P.
Inventor： Elinor Dehan , Bhuvan Sharma , Claudia S. Huettner , Kirk Alan Beaty , Shang Xue , Himanshu Sharma
Abstract: A mechanism is provided for processing electronic files to identify genetic variants of a gene. Evidence of one or more genetic variants of the gene and corresponding information is extracted from a corpus of information. Each genetic variant of the one or more genetic variants is classified based on whether the genetic variant is identified as being pathogenic. Genetic variant annotation is then performed to generate a summary.
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公开(公告)号：US11721441B2
公开(公告)日：2023-08-08
申请号：US16248084
申请日：2019-01-15
Applicant: Merative US L.P.
Inventor： Cheryl L. Eifert , Jia Xu , Claudia S Huettner , Fang Wang , Vanessa Michelini , Elinor Dehan
Abstract: Computer based methods, systems, and computer readable media for intelligently accessing various types of pharmaceutical information in a content repository and ranking drugs at the variant level, gene level, and pathway level. In some cases, drugs that target the same gene, gene variant, or biological pathway may be ranked based upon in vitro, pre-clinical, clinical, or post-clinical evidence. To determine ranking of a plurality of drugs, information pertaining to drug administration is analyzed for the drugs. For a plurality of drugs, attributes corresponding to the drug are determined, wherein the attributes include a variant or a gene targeted by the drug, and a biological pathway comprising the targeted variant or gene. The plurality of drugs are ranked according to a drug effectiveness score based on one or more of a determined efficacy, potency, or toxicity.
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