公开(公告)号：US11721441B2

公开(公告)日：2023-08-08

申请号：US16248084

申请日：2019-01-15

Applicant: Merative US L.P.

Inventor： Cheryl L. Eifert ,  Jia Xu ,  Claudia S Huettner ,  Fang Wang ,  Vanessa Michelini ,  Elinor Dehan

IPC: G16H70/40 ,  G16B50/00 ,  G16B40/00 ,  G16H70/60

CPC classification number: G16H70/40 ,  G16B40/00 ,  G16B50/00 ,  G16H70/60

Abstract: Computer based methods, systems, and computer readable media for intelligently accessing various types of pharmaceutical information in a content repository and ranking drugs at the variant level, gene level, and pathway level. In some cases, drugs that target the same gene, gene variant, or biological pathway may be ranked based upon in vitro, pre-clinical, clinical, or post-clinical evidence. To determine ranking of a plurality of drugs, information pertaining to drug administration is analyzed for the drugs. For a plurality of drugs, attributes corresponding to the drug are determined, wherein the attributes include a variant or a gene targeted by the drug, and a biological pathway comprising the targeted variant or gene. The plurality of drugs are ranked according to a drug effectiveness score based on one or more of a determined efficacy, potency, or toxicity.