公开(公告)号：US20140046181A1

公开(公告)日：2014-02-13

申请号：US13978140

申请日：2012-01-05

申请人： Michael Benchimol ,  Sadik C. Esener ,  Dmitri Simberg ,  Stuart Ibsen

发明人： Michael Benchimol ,  Sadik C. Esener ,  Dmitri Simberg ,  Stuart Ibsen

IPC分类号： A61K41/00 ,  A61M5/00 ,  A61M37/00

CPC分类号： A61K41/0047 ,  A61K9/0009 ,  A61K9/1273 ,  A61K41/0028 ,  A61M5/007 ,  A61M37/0092

摘要： Techniques, systems, devices and materials are disclosed for implementing and fabricating drug delivery and imaging vehicles, which are activated in the body at a tissue of interest by focused ultrasound. In one aspect, a drug delivery vehicle can include a carrier having an outer membrane that envelopes an acoustic sensitizer particle and a payload substance to be delivered to the target tissue. The outer membrane can protect the acoustic sensitizer particle and the payload substance from degradation and opsonization. The outer membrane can be functionalized with a tumor targeting ligand to cause the drug delivery vehicle to selectively accumulate in a tumor region over other tissues, as well as with an agent to increase circulation time by reducing uptake from undesired body tissues, organs, and systems.

摘要翻译： 公开了用于实施和制造药物递送和成像载体的技术，系统，装置和材料，其通过聚焦超声在感兴趣的组织在体内被激活。 在一个方面，药物递送载体可以包括具有外膜的载体，其包围声敏剂颗粒和有效载体物质被输送到目标组织。 外膜可以保护声学敏化剂颗粒和有效载荷物质免于降解和调理。 外膜可以用肿瘤靶向配体进行功能化，以使药物递送媒介物在其他组织上选择性地积聚在肿瘤区域中，以及通过减少来自不期望的身体组织，器官和系统的摄取而增加循环时间的试剂 。