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1.发明申请Protein N-glycosylation of eukaryotic cells using dolichol-linked oligosaccharide synthesis pathway, other N-gylosylation-increasing methods, and engineered hosts expressing products with increased N-glycosylation 审中-公开使用二烯醇连接的寡糖合成途径，其他N-甲氧基化增加方法的真核细胞的蛋白质N-糖基化和表达具有增加的N-糖基化的产物的工程改造的宿主公开(公告)号：US20060252672A1
公开(公告)日：2006-11-09
申请号：US11397907
申请日：2006-04-05
CPC分类号： A61K38/45 , A61K47/543 , A61K47/549 , A61K48/00 , A61K48/005 , C12N9/1085 , C12N9/1205 , C12P21/005
摘要： The level of glycosylation on products produced by a host (such as CHO cells, HEK cells and other mammalian cells, and non-mammalian cells) or patient can be increased by engineering, such as by supplying the host or patient with a gene sequence. For example, the host or patient can be made to produce desirably glycosylated products by increasing one or both of expression of N-glycan substrate containing lipid-liked oligosaccharide and expression of oligosaccharide (OST) transferase.
摘要翻译： 由宿主（如CHO细胞，HEK细胞和其他哺乳动物细胞以及非哺乳动物细胞）或患者产生的产物上的糖基化水平可以通过工程来增加，例如通过向宿主或患者提供基因序列。 例如，通过增加含有脂质寡糖的N-聚糖底物的表达和寡糖（OST）转移酶的表达的一种或两种，可以使宿主或患者制成合适的糖基化产物。
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