专利检索 ap:("Michael RENZI" OR "Navneeth Thirumalai" OR "Linda Jolliffe" OR "Francis Farrell") AND inv:"Michael RENZI" 第 1 页

1.

发明申请
METHODS FOR SHP1 MEDIATED NEUROPROTECTION 审中-公开

公开(公告)号：US20070009967A1

公开(公告)日：2007-01-11

申请号：US11530222

申请日：2006-09-08

申请人： Michael RENZI , Navneeth Thirumalai , Linda Jolliffe , Francis Farrell

发明人： Michael RENZI , Navneeth Thirumalai , Linda Jolliffe , Francis Farrell

IPC分类号： G01N33/567 , G01N33/53

CPC分类号： G01N33/573 , A61K31/00 , A61K31/381 , A61K31/426 , A61K31/427 , A61K38/1816 , C12Q1/44 , G01N2500/02 , G01N2500/04 , G01N2500/10 , A61K2300/00

摘要： The effect of EPO on the phosphorylation of the EPO receptor, the activation of the MAP Kinase pathway, and the expression of SHP-1 were analyzed. EPO was observed to cause a decrease in the expression of its negative regulator SHP-1. The decrease observed at both the mRNA and protein level was dose dependent and persisted as long as 24 hr following EPO treatment. EPO can down regulate the expression of its own negative regulator as a means for increased potency in neurons. Assays were generated to identify compounds that are useful in regulating SHP1 activity in neural cells.