公开(公告)号：US20190119357A1

公开(公告)日：2019-04-25

申请号：US15743112

申请日：2016-07-22

Applicant: ModernaTX, Inc.

Inventor： Eric Yi-chun HUANG ,  Josh FREDERICK ,  Kristine MCKINNEY ,  Christina HENDERSON ,  Kahlin CHEUNG-ONG ,  Joseph BOLEN ,  Stephen Michael KELSEY ,  Michael MORIN ,  Sushma GURUMURTHY

IPC: C07K14/81 ,  C07K14/47 ,  A61K9/127 ,  A61K47/69 ,  A61P35/00 ,  A61P35/02 ,  A61K9/00 ,  A61K9/51 ,  C07K16/28 ,  A61K39/395 ,  A61K38/57 ,  A61K38/17

Abstract: The invention features isolated mRNAs encoding fusion polypeptides comprising a Stefm A (SteA) scaffold polypeptide and one or more binding polypeptides, such as one or more Bc1-2 homology 3 (BH3) domains, including mRNAs comprising one or more modified nucleobase, and methods of using the same, for example, for inducing apoptosis and/or treating cancer (e.g., liver cancer or colorectal cancer).

公开(公告)号：US20170210788A1

公开(公告)日：2017-07-27

申请号：US15328187

申请日：2015-07-23

Applicant: ModernaTX, Inc.

Inventor： Eric Yi-Chun HUANG ,  Josh FREDERICK ,  Kristine MCKINNEY ,  Christina HENDERSON

IPC: C07K16/18 ,  A61K48/00 ,  C07K14/79 ,  A61K9/16 ,  C07K14/78 ,  C07K14/81

CPC classification number: C07K16/18 ,  A61K9/1617 ,  A61K48/0066 ,  A61K2039/505 ,  C07K14/00 ,  C07K14/78 ,  C07K14/79 ,  C07K14/8114 ,  C07K14/8139 ,  C07K16/00 ,  C07K16/082 ,  C07K16/30 ,  C07K2317/21 ,  C07K2317/569 ,  C07K2317/60 ,  C07K2317/76 ,  C07K2317/80 ,  C07K2317/94 ,  C07K2318/20 ,  C07K2319/70 ,  C12N15/87

Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of modified polynucleotides comprising at least one intrabody construct.