公开(公告)号：US20190119357A1

公开(公告)日：2019-04-25

申请号：US15743112

申请日：2016-07-22

Applicant: ModernaTX, Inc.

Inventor： Eric Yi-chun HUANG ,  Josh FREDERICK ,  Kristine MCKINNEY ,  Christina HENDERSON ,  Kahlin CHEUNG-ONG ,  Joseph BOLEN ,  Stephen Michael KELSEY ,  Michael MORIN ,  Sushma GURUMURTHY

IPC: C07K14/81 ,  C07K14/47 ,  A61K9/127 ,  A61K47/69 ,  A61P35/00 ,  A61P35/02 ,  A61K9/00 ,  A61K9/51 ,  C07K16/28 ,  A61K39/395 ,  A61K38/57 ,  A61K38/17

Abstract: The invention features isolated mRNAs encoding fusion polypeptides comprising a Stefm A (SteA) scaffold polypeptide and one or more binding polypeptides, such as one or more Bc1-2 homology 3 (BH3) domains, including mRNAs comprising one or more modified nucleobase, and methods of using the same, for example, for inducing apoptosis and/or treating cancer (e.g., liver cancer or colorectal cancer).

公开(公告)号：US20210206818A1

公开(公告)日：2021-07-08

申请号：US16071131

申请日：2017-01-20

Applicant: ModernaTX, Inc.

Inventor： Eric Yi-Chun HUANG ,  Joshua P. FREDERICK ,  Kristine MCKINNEY ,  Christina HENDERSON ,  Kahlin CHEUNG-ONG ,  Joseph BOLEN ,  Stephen Michael KELSEY ,  Michael MORIN ,  Sushma GURUMURTHY ,  Kerry BENENATO ,  Stephen HOGE ,  Iain MCFADYEN ,  Vladimir PRESNYAK

IPC: C07K14/47 ,  A61K9/51 ,  A61P35/00

Abstract: The invention features isolated mRNAs encoding at least one intracellular binding domain, including mRNAs comprising one or more modified nucleobase and preferably lacking an encoded scaffold polypeptide, and methods of using the same, for example, for inducing apoptosis and/or treating cancer (e.g., liver cancer or colorectal cancer).