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公开(公告)号:US20100003675A1
公开(公告)日:2010-01-07
申请号:US12223689
申请日:2007-02-05
申请人: Mogens Sando Lund , Bente Flugel Majgren , Goutam Sahana , Ayman Mahmoud Sabry , Peter Sorensen , Soren Svendsen , Bo Thomsen , Ingrid Lena Anderson-Eklund , Helmi Johanna Vilkki , Christian Bendixen , Terhi Katariina Iso-Touru , Sirja Maria Viitala , Nina Frederika Schulman , Nicola Hastings , John Lewis William Williams , John Arthur Woolliams , Ana Isabel Fernandez Avila , Haldja Viinalass , Sirje Varv
发明人: Mogens Sando Lund , Bente Flugel Majgren , Goutam Sahana , Ayman Mahmoud Sabry , Peter Sorensen , Soren Svendsen , Bo Thomsen , Ingrid Lena Anderson-Eklund , Helmi Johanna Vilkki , Christian Bendixen , Terhi Katariina Iso-Touru , Sirja Maria Viitala , Nina Frederika Schulman , Nicola Hastings , John Lewis William Williams , John Arthur Woolliams , Ana Isabel Fernandez Avila , Haldja Viinalass , Sirje Varv
IPC分类号: C12Q1/68
CPC分类号: C12Q1/6883 , C12Q2600/118 , C12Q2600/156 , C12Q2600/16 , C12Q2600/172
摘要: The invention relates to a method for determining mastitis resistance in bovine subjects, wherein mastitis resistance comprise resistance to both sub-clinical and clinical mastitis. In particular, the method of the invention involves identification of genetic markers and/or Quantitative Trait Locus (QTL) for the determination of mastitis resistance in a bovine subject. The determination of mastitis resistance involves resolution of the specific microsatellite status. Furthermore, the invention relates to a diagnostic kit for detection of genetic marker(s) associated with mastitis resistance. The method and kit of the present invention can be applied for selection of bovine subjects for breeding purposes. Thus, the invention provides a method of genetically selecting bovine subjects with mastitis resistance, thereby yielding cows less prone to mastitis.
摘要翻译: 本发明涉及一种用于确定牛受试者的乳房炎抵抗的方法,其中乳腺炎抗性包括对亚临床和临床乳腺炎的抗性。 特别地,本发明的方法涉及鉴定用于测定牛受试者的乳腺炎抵抗的遗传标记和/或定量性状基因座(QTL)。 确定乳腺炎的耐药性包括解决特定的微卫星状态。 此外,本发明涉及用于检测与乳腺炎抵抗相关的遗传标记的诊断试剂盒。 本发明的方法和试剂盒可用于选择用于育种目的的牛受试者。 因此,本发明提供了一种遗传性选择具有乳腺炎抗性的牛受试者的方法,从而产生不易发生乳腺炎的母牛。