公开(公告)号：US20220366552A1

公开(公告)日：2022-11-17

申请号：US17766088

申请日：2020-08-18

Applicant: NANJING UNIVERSITY OF SCIENCE AND TECHNOLOGY

Inventor： Qian CHEN ,  Yao FAN ,  Chao ZUO ,  Jiasong SUN ,  Xiangpeng PAN ,  Shijie FENG ,  Yuzhen ZHANG ,  Guohua GU ,  Jiaji LI ,  Jialin ZHANG

IPC: G06T5/50 ,  G02B21/36

Abstract: A single-shot differential phase contrast quantitative phase imaging method based on color multiplexing illumination. A color multiplexing illumination solution is used to realize single-shot differential phase contrast quantitative phase imaging. In the single-shot color multiplexing illumination solution, three illumination wavelengths of red, green, and blue are used to simultaneously illuminate a sample, and the information of the sample in multiple directions is converted into intensity information on different channels of a color image. By performing channel separation on this color image, the information about the sample at different spatial frequencies can be obtained. Such a color multiplexing illumination solution requires only one acquired image, thus enhancing the transfer response of the phase transfer function of single-shot differential phase contrast imaging in the entire frequency range, and achieving real-time dynamic quantitative phase imaging with a high contrast, a high resolution, and a high stability. In addition, an alternate illumination strategy is provided, so that a completely isotropic imaging resolution at the limit acquisition speed of the camera can be achieved.