公开(公告)号：US3852414A

公开(公告)日：1974-12-03

申请号：US28868372

申请日：1972-09-13

申请人： NEW ENGLAND NUCLEAR CORP

发明人： ADLER N ,  GAMIN L

IPC分类号： A61K51/04 ,  A61K27/04

CPC分类号： A61K51/0489 ,  A61K2123/00

摘要： A metabolizable radioactive technetium-99m-stannous-ring phosphate complex in which at least 15 to 20% by weight, and preferably 40 to 100%, of the phosphate moiety is a ring or cyclic phosphate of molecular weight less than 300 and in which no more than 5 to 15% or 20% by weight of such phosphate moiety is a linear polyphosphate of molecular weight greater than pyrophosphate, a method of making the same, a method of using the same by in vivo intravenous administration to a mammal of the sterile-non-pyrogenic complex followed by radioassay scanning or imaging the skeletal structure, and a kit made up of a stannousphosphate complex in which at least 15 to 20% and preferably 40 to 99% of the phosphate moiety is the aforesaid ring or cyclic phosphate and in which no more than 5 to 15% or 20% by weight of such phosphate moiety is a linear polyphosphate of molecular weight greater than pyrophosphate.

摘要翻译： 一种可代谢的放射性锝-99m-亚锡环磷酸盐络合物，其中至少15-20％重量，优选40-100％的磷酸酯部分是分子量小于300的环或环状磷酸酯，其中不含 大于5至15重量％或20重量％的这种磷酸酯部分是分子量大于焦磷酸盐的线性多磷酸盐，其制备方法，通过体内静脉内给予无菌哺乳动物的方法 - 非热原复合物，然后进行放射性测定扫描或成像骨架结构，以及由磷酸亚锡配合物制成的试剂盒，其中至少15-20％，优选40-99％的磷酸酯部分是前述的环或环状 磷酸盐，其中不超过5至15重量％或20重量％的这种磷酸盐部分是分子量大于焦磷酸盐的线性多磷酸盐。