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公开(公告)号：US3826059A
公开(公告)日：1974-07-30
申请号：US29779172
申请日：1972-10-16
发明人： NOVITCH H
CPC分类号： B65D55/0854 , B65B53/00 , B65D51/002
摘要： A dually sealable, non-leaking vial for shipping liquid radioactive materials, particularly sterile radioactive materials, and other sterile liquid materials in which the mouth of the vial, as shipped, is sealed by a needle pierceable septum seal and in which a threaded cap is located and held over the septum seal and mouth with the threads thereby held out of engagement with mating threads on the vial by the septum seal. However, upon removal of the sepum seal after shipment, the threads of the cap mate with the threads of the vial whereby the cap can be removably threaded tightly over the mouth to seal it. The capped and septum-sealed loaded vial is placed in a heat shrinkable plastic envelope having a bottom end wall and an upstanding cylindrical wall of greater height than the capped, septum-sealed vial and of lesser thickness than the bottom end wall and the envelope is heat shrunk circumferentially, tightly and sealably around the capped septum-sealed vial with the upper part of the envelope being shrunk circumferentially and downwardly tightly over the margin of the upper surface of the cap to securely seal the capped septum-sealed vial.
摘要翻译： 用于运送液体放射性物质，特别是无菌放射性物质的双重密封，不泄漏的小瓶以及其他无菌液体材料，其中小瓶的口腔运送时由可刺针的隔垫密封件密封，并且其中螺纹帽 位于并保持在隔膜密封件和口部上的螺纹，从而通过隔膜密封件与小瓶上的配合螺纹保持不接合。 然而，在装运后去除间隔密封件时，盖子的螺纹与小瓶的螺纹配合，由此盖子可以可移除地拧紧在口上以将其密封。
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公开(公告)号：US3774035A
公开(公告)日：1973-11-20
申请号：US3774035D
申请日：1971-07-12
发明人： LITT G
CPC分类号： G21G4/06 , G21G1/0005 , G21G1/02 , G21G4/08
摘要： A method and system for filling a vial with an eluate containing a radionuclide by coupling a vial containing a prepackaged amount of eluant to both an inlet to a radionuclide generator column and a vent outlet and coupling an evacuated vial to an outlet from the radionuclide column. The method and system may utilize a filter which includes an eluate repellent portion.
摘要翻译： 通过将含有预包装量的洗脱液的小瓶与放射性核素发生器塔的入口和排气口连接，将抽真空的小瓶耦合到放射性核素柱的出口，来填充含有放射性核素的洗脱液的小瓶的方法和系统。 该方法和系统可以使用包括洗脱剂驱避部分的过滤器。
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3.发明授权Method and apparatus for measuring the amount of a component in a biological fluid 失效用于测量生物流体中组分的量的方法和装置
公开(公告)号：US3615222A
公开(公告)日：1971-10-26
申请号：US3615222D
申请日：1968-09-04
发明人： MEAD LOUIS W
IPC分类号： B01L3/14 , G01N33/538 , G01N33/78 , G01N23/00 , G01N33/16
CPC分类号： B01L3/5082 , G01N33/538 , G01N33/78 , Y10S436/81 , Y10S436/825 , Y10S436/826
摘要： A technique for clinically measuring the amount of a component, such as thyroxine, in a biological fluid, such as serum, of the type in which the amount of such component bound to a binding agent therefor, such as a protein, is measured by measuring the capacity of the binding agent to bind a tracer labeled compound and in which such capacity is measured by the use of a solid particulate adsorbent or absorbent for selectively adsorbing or absorbing the unbound tracer labeled compound from a liquid containing the same together with the bound tracer labeled compound and the bound component, the improvement comprising mixing the solid adsorbent and liquid in a container in which the solid particulate adsorbent is secured to the upper end thereof and the liquid is contained in the lower end, the mixing being carried out by inversion of the container. By this procedure, it is possible to simultaneously mix the solids and liquids of a plurality of specimens and controls and to thereby simultaneously incubate and centrifuge them to insure that all specimens and controls are subjected to identical conditions to thereby minimize errors and the time required to carry out such measurements. The compounds used for carrying out the tests may be conveniently stored and shipped in the same container in which mixing, incubation, centrifuging and tracer measurement are carried out and which is in the form of a transparent or translucent, relatively rigid, tubular vial of a molded resin made up of two parts, in one of which is secured the adsorbent and in the other of which is located the liquid. During shipment and storage one part functions as a cap for the other, which is also capped and when the test is to be carried out, the parts are disassembled and reassembled with the open mouths of the two parts mated together to form a single chamber and with the solids-containing part located above the liquid-containing part so that the solids secured in the upper part do not come in contact with the liquid in the lower part until the container is inverted.
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公开(公告)号：US3852414A
公开(公告)日：1974-12-03
申请号：US28868372
申请日：1972-09-13
CPC分类号： A61K51/0489 , A61K2123/00
摘要： A metabolizable radioactive technetium-99m-stannous-ring phosphate complex in which at least 15 to 20% by weight, and preferably 40 to 100%, of the phosphate moiety is a ring or cyclic phosphate of molecular weight less than 300 and in which no more than 5 to 15% or 20% by weight of such phosphate moiety is a linear polyphosphate of molecular weight greater than pyrophosphate, a method of making the same, a method of using the same by in vivo intravenous administration to a mammal of the sterile-non-pyrogenic complex followed by radioassay scanning or imaging the skeletal structure, and a kit made up of a stannousphosphate complex in which at least 15 to 20% and preferably 40 to 99% of the phosphate moiety is the aforesaid ring or cyclic phosphate and in which no more than 5 to 15% or 20% by weight of such phosphate moiety is a linear polyphosphate of molecular weight greater than pyrophosphate.
摘要翻译： 一种可代谢的放射性锝-99m-亚锡环磷酸盐络合物，其中至少15-20％重量，优选40-100％的磷酸酯部分是分子量小于300的环或环状磷酸酯，其中不含 大于5至15重量％或20重量％的这种磷酸酯部分是分子量大于焦磷酸盐的线性多磷酸盐，其制备方法，通过体内静脉内给予无菌哺乳动物的方法 - 非热原复合物，然后进行放射性测定扫描或成像骨架结构，以及由磷酸亚锡配合物制成的试剂盒，其中至少15-20％，优选40-99％的磷酸酯部分是前述的环或环状 磷酸盐，其中不超过5至15重量％或20重量％的这种磷酸盐部分是分子量大于焦磷酸盐的线性多磷酸盐。
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公开(公告)号：US3811591A
公开(公告)日：1974-05-21
申请号：US29781072
申请日：1972-10-16
发明人： NOVITCH H
CPC分类号： B65D51/002 , B65D55/0854
摘要： A dually sealable, non-leaking vial for shipping liquid radioactive materials, particularly sterile radioactive materials, and other sterile liquid materials in which the mouth of the vial, as shipped, is sealed by a needle pierceable septum seal and in which a threaded cap is located and held over the septum seal and mouth with the threads thereby held out of engagement with mating threads on the vial by the septum seal. However, upon removal of the septum seal after shipment, the threads of the cap mate with the threads of the vial whereby the cap can be removably threaded tightly over the mouth to seal it. The capped and septum-sealed loaded vial is placed in a heat shrinkable plastic envelope having a bottom end wall and an upstanding cylindrical wall of greater height than the capped, septum-sealed vial and of lesser thickness than the bottom end wall and the envelope is heat shrunk circumferentially, tightly and sealably around the capped septum-sealed vial with the upper part of the envelope being shrunk circumferentially and downwardly tightly over the margin of the upper surface of the cap to securely seal the capped septum-sealed vial.
摘要翻译： 用于运送液体放射性物质，特别是无菌放射性物质的双重密封，不泄漏的小瓶以及其他无菌液体材料，其中小瓶的口腔运送时由可刺针的隔垫密封件密封，并且其中螺纹帽 位于并保持在隔膜密封件和口部上的螺纹，从而通过隔膜密封件与小瓶上的配合螺纹保持不接合。 然而，在装运之后移除隔垫密封件时，盖的螺纹与小瓶的螺纹配合，由此盖可以可移除地拧紧在口上以将其密封。
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公开(公告)号：US3657541A
公开(公告)日：1972-04-18
申请号：US3657541D
申请日：1969-08-04
发明人： DEUTSCH MARSHALL E , MEAD LOUIS W , NAGY ZOLTAN
CPC分类号： G21F5/00 , G01T1/167 , G21G1/0005 , G21H5/00
摘要： This invention relates to the generation and testing of radionuclides, and more particularly, to the generation and testing of radionuclides for use in nuclear medicine.
摘要翻译： 本发明涉及放射性核素的产生和测试，更具体地说，涉及用于核医学的放射性核素的产生和测试。
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公开(公告)号：US3851044A
公开(公告)日：1974-11-26
申请号：US28857772
申请日：1972-09-13
CPC分类号： A61K51/02 , A61K2123/00
摘要： 1. A METABOLIZABLE RADIOACTIVE BONE SEEKING COMPOSITION FOR IN VIVO CONCENTRATING 99M TC IN THE SKELETAL STRUCTURE OF MAMMALS COMPRISING A TECHNETIUM-99M-STANNOUSPHOSPHATE COMPLEX, THE PHOSPHATE MOETY OF WHICH COMPRISES PYROPHOSPHATE, SAID PHOSPHATE MOIETY CONTAINING NO MORE THAN 25% BY WEIGHT OF LINEAR POLYPHOSPHATE OF FORMULATION PNO3N+1-(N+2) HAVING A MOLECULAR WEIGHT GREATER THAN PYROSPHOSPHATE.
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公开(公告)号：US3770155A
公开(公告)日：1973-11-06
申请号：US3770155D
申请日：1971-10-19
发明人： NOVITCH H
CPC分类号： B65D55/0854 , B65D51/002 , Y10S215/03
摘要： A dually sealable, non-leaking vial for shipping liquid radioactive materials, particularly sterile radioactive materials, and other sterile liquid materials in which the mouth of the vial, as shipped, is sealed by a needle pierceable septum seal and in which a threaded cap is located and held over the septum seal and mouth with the threads thereby held out of engagement with mating threads on the vial by the septum seal. However, upon removal of the septum seal after shipment, the threads of the cap mate with the threads of the vial whereby the cap can be removabley threaded tightly over the mouth to seal it. The capped and septum-sealed loaded vial is placed in a heat shrinkable plastic envelope having a bottom end wall and an upstanding cylindrical wall of greater height than the capped, septum-sealed vial and of lesser thickness than the bottom end wall and the envelope is heat shrunk circumferentially, tightly and sealably around the capped septum-sealed vial with the upper part of the envelope being shrunk circumferentially and downwardly tightly over the margin of the upper surface of the cap to securely seal the capped septum-sealed vial.
摘要翻译： 用于运送液体放射性物质，特别是无菌放射性物质的双重密封，不泄漏的小瓶以及其他无菌液体材料，其中小瓶的口腔运送时由可刺针的隔垫密封件密封，并且其中螺纹帽 位于并保持在隔膜密封件和口部上的螺纹，从而通过隔膜密封件与小瓶上的配合螺纹保持不接合。 然而，在出货之后移除隔垫密封件时，盖的螺纹与小瓶的螺纹配合，由此盖可以紧紧地在口上被拧紧以将其密封。
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公开(公告)号：US3561932A
公开(公告)日：1971-02-09
申请号：US3561932D
申请日：1967-01-26
发明人： GRUVERMAN IRWIN J , ROCCO GREGORY G
CPC分类号： G21G1/0005 , C01G15/00 , G21G2001/0057
摘要： A GENERATOR OF A DAUGHTER RADIONUCLIDE, PARTICULARLY RADIOACTIVE INDIUM (IN113M), AND A METHOD OF LOADING A PARTICULATE SUBSTRATE OF THE GENERATOR WITH A PARENT RADIONUCLIDE. THE DAUGHTER RADIONUCLIDE, WHICH RESULTS FROM THE RADIOACTIVE DECAY OF ITS PARENT, IS SELECTIVELY EXTRACTED FROM THE SUBSTRATE BY A MINERAL ACID SOOLVENT (ELUANT),
SUCH AS HYDROCHLORIC ACID (HC1) AT A CONCENTRATION LESS THAN ONE-TENTH NORMAL (0.1 N).-
公开(公告)号：US3848773A
公开(公告)日：1974-11-19
申请号：US23257672
申请日：1972-03-07
发明人： GOLD P , ADLER N , MORGENTHAU J
CPC分类号： A61M5/00
摘要： A device and method for dispensing a pre-measured amount of gas, such as a radioactive gas, contained in a sealed vial having a pierceable septum. A plurality of such vials are stored in an end-to-end relationship in a shielded tubular storage means. The dispensing device includes a dispenser portion having a pair of needles respectively connected to a gas dispensing adapter and displacement fluid intake adapter. One of the sealed vials is removed from the storage means and retained in a holder which is then inserted into the dispenser portion so that the septum of the vial is in a position opposite the ends of the needles. The vial is moved within the holder toward the needles so that the septum is pierced by the latter. Means are provided for injecting a displacement fluid, which in a particular embodiment may be air, into the vial through the fluid intake adapter and the needle connected thereto, thereby forcing the radioactive gas out from the vial through the other needle to the gas dispensing adapter for use in an appropriate instrument which, for example, may be a breathing apparatus, such as an oral syringe or a spirometer.
摘要翻译： 用于分配包含在具有可穿透隔膜的密封小瓶中的预先测量量的诸如放射性气体的气体的装置和方法。 多个这样的小瓶在屏蔽的管状存储装置中以端对端关系存储。 分配装置包括分配器部分，其具有分别连接到气体分配适配器和置换流体进料适配器的一对针。 密封的小瓶中的一个从存储装置中取出并保持在保持器中，然后插入到分配器部分中，使得小瓶的隔膜处于与针的端部相对的位置。 小瓶在保持器内朝向针移动，使得隔膜被后者刺穿。 提供了用于通过流体进料适配器和连接到其上的针将可移动流体（在特定实施例中可以是空气）注入小瓶中的装置，从而迫使放射性气体从小瓶通过另一针排出到气体分配适配器 用于适当的仪器，例如可以是呼吸器，例如口腔注射器或肺活量计。
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