公开(公告)号：US20180002368A1

公开(公告)日：2018-01-04

申请号：US15536516

申请日：2015-12-16

Applicant: NOVARTIS AG

Inventor： David BARNES-SEEMAN ,  Scott Louis COHEN ,  John Louis DIENER ,  Christian GAMPE ,  James ROACHE ,  Amy WHITE ,  Sarah WILLIAMS ,  Jun YUAN ,  Frederic ZECRI

IPC: C07H21/02 ,  C07F9/6561 ,  C07H19/207 ,  C07K14/575

Abstract: The disclosure relates to nucleic acids that contain modifications at the 5′-end, 3′-end or 5′-end and 3′-ends, and compounds that can be used to make the modified nucleic acids arc disclosed. The modified nucleic acids have improved expression, lower immunogenicity and improved stability compared to unmodified nucleic acids.