公开(公告)号：US20220340573A1

公开(公告)日：2022-10-27

申请号：US17805487

申请日：2022-06-06

Applicant: Novartis AG

Inventor： Kelly D. BOSS ,  Yi FAN ,  Alec Nathanson FLYER ,  Declan HARDY ,  Zhihong HUANG ,  Kathryn Taylor LINKENS ,  Jon Christopher LOREN ,  Fupeng MA ,  Valentina MOLTENI ,  Duncan SHAW ,  Jeffrey SMITH ,  Catherine Fooks SOLOVAY

IPC: C07D471/10 ,  A61P27/04 ,  C07D413/06 ,  C07D413/14 ,  C07D491/107

Abstract: Provided herein are compounds and pharmaceutical compositions useful for treating meibomian gland dysfunction (MGD), comprising administering to a subject in need thereof a therapeutically effective amount of a compound of Formula (I) or a compound of Formula (I′), or pharmaceutical composition described herein.

公开(公告)号：US20220064164A1

公开(公告)日：2022-03-03

申请号：US17101510

申请日：2020-11-23

Applicant: NOVARTIS AG

Inventor： Kelly D. BOSS ,  Yi FAN ,  Alec Nathanson FLYER ,  Declan HARDY ,  Zhihong HUANG ,  Kathryn Taylor LINKENS ,  Jon Christopher LOREN ,  Fupeng MA ,  Valentina MOLTENI ,  Duncan SHAW ,  Jeffrey SMITH ,  Catherine Fooks SOLOVAY

IPC: C07D471/10 ,  C07D413/14 ,  C07D413/06 ,  C07D491/107 ,  A61P27/04

Abstract: Provided herein are compounds and pharmaceutical compositions useful for treating meibomian gland dysfunction (MGD), comprising administering to a subject in need thereof a therapeutically effective amount of a compound of Formula (I) or a compound of Formula (I′), or pharmaceutical composition described herein.