公开(公告)号：US20240238305A1

公开(公告)日：2024-07-18

申请号：US18561444

申请日：2022-05-18

Applicant: Novartis AG

Inventor： Yi FAN ,  Declan HARDY ,  Zhihong HUANG ,  Jay Parthiban LAKSHMAN ,  Jon Christopher LOREN ,  Valentina MOLTENI ,  Sunil Kumar Mandala RAYABANDLA ,  Nuria Jimenez RIDRUEJO ,  Duncan SHAW ,  Jeffrey SMITH ,  Christopher Stephen TOWLER

IPC: A61K31/5377 ,  A61K9/00 ,  A61K9/10 ,  A61K47/10 ,  A61K47/18 ,  A61K47/26 ,  A61K47/32 ,  A61K47/44 ,  A61P27/04

CPC classification number: A61K31/5377 ,  A61K9/0048 ,  A61K9/10 ,  A61K47/10 ,  A61K47/18 ,  A61K47/26 ,  A61K47/32 ,  A61K47/44 ,  A61P27/04

Abstract: Formulations of 3-((3-(4-(2-(isobutylsulfonyl)phenoxy)-3-(trifluoromethyl)phenyl)-1,2,4-oxadiazol-5-yl)methyl)-5,5-dimethyl-1-(2-morpholinoethyl)imidazolidine-2,4-dione and pharmaceutically acceptable salts thereof, processes for their production, and uses thereof, including in the treatment of ocular diseases and disorders such as dry eye disease and Meibomian gland dysfunction (MGD).

公开(公告)号：US20220064164A1

公开(公告)日：2022-03-03

申请号：US17101510

申请日：2020-11-23

Applicant: NOVARTIS AG

Inventor： Kelly D. BOSS ,  Yi FAN ,  Alec Nathanson FLYER ,  Declan HARDY ,  Zhihong HUANG ,  Kathryn Taylor LINKENS ,  Jon Christopher LOREN ,  Fupeng MA ,  Valentina MOLTENI ,  Duncan SHAW ,  Jeffrey SMITH ,  Catherine Fooks SOLOVAY

IPC: C07D471/10 ,  C07D413/14 ,  C07D413/06 ,  C07D491/107 ,  A61P27/04

Abstract: Provided herein are compounds and pharmaceutical compositions useful for treating meibomian gland dysfunction (MGD), comprising administering to a subject in need thereof a therapeutically effective amount of a compound of Formula (I) or a compound of Formula (I′), or pharmaceutical composition described herein.

公开(公告)号：US20220340573A1

公开(公告)日：2022-10-27

申请号：US17805487

申请日：2022-06-06

Applicant: Novartis AG

Inventor： Kelly D. BOSS ,  Yi FAN ,  Alec Nathanson FLYER ,  Declan HARDY ,  Zhihong HUANG ,  Kathryn Taylor LINKENS ,  Jon Christopher LOREN ,  Fupeng MA ,  Valentina MOLTENI ,  Duncan SHAW ,  Jeffrey SMITH ,  Catherine Fooks SOLOVAY

IPC: C07D471/10 ,  A61P27/04 ,  C07D413/06 ,  C07D413/14 ,  C07D491/107

Abstract: Provided herein are compounds and pharmaceutical compositions useful for treating meibomian gland dysfunction (MGD), comprising administering to a subject in need thereof a therapeutically effective amount of a compound of Formula (I) or a compound of Formula (I′), or pharmaceutical composition described herein.