公开(公告)号：US4307100A

公开(公告)日：1981-12-22

申请号：US67439

申请日：1979-08-20

申请人： Nicole Langlois ,  Yves Langlois ,  Ratremaniaina Z. Andriamialisoa ,  Pierre Potieo ,  Pierre Mangeney

发明人： Nicole Langlois ,  Yves Langlois ,  Ratremaniaina Z. Andriamialisoa ,  Pierre Potieo ,  Pierre Mangeney

IPC分类号： C07D519/04 ,  A61K31/475

CPC分类号： C07D519/04

摘要： Compounds with antitumoral activity corresponding to the formula (I): ##STR1## wherein R'.sub.1 is a hydrogen atom or an alkoxy, acyl, formyl or haloacyl radical; R'.sub.2 is a hydrogen atom or an alkyl radical; R'.sub.3 and R".sub.3 are a hydrogen atom, hydroxyl radical or an alkanoyloxy radical, and together are a carbonyl group, and R'.sub.3 and R'.sub.5 together are an epoxy bridge or a double bond; R'.sub.4 is a hydrogen atom or an alkyloxycarbonyl, hydroxymethyl, alkanoyloxymethyl or acetamido radical; R'.sub.5 and R".sub.5 are a hydrogen atom or a hydroxyl, alkanoyloxyl, ethyl or 2-hydroxyethyl radical; R'.sub.6 is a hydrogen atom or an ethyl, 2-hydroxyethyl or acetyl radical; R.sub.1 is a hydrogen atom or an alkyl, formyl or acyl radical; R.sub.2 is a hydrogen atom or alkoxy radical; R.sub.3 is a hydrogen atom or a hydroxyl or alkanoyloxyl radical, and together with R.sub.4 is an epoxy bridge or a double bond; R.sub.4 is a hydrogen atom or a hydroxyl, alkanoyloxyl radical, and together with R.sub.5 is an epoxy bridge; R.sub.6 is an alkyloxycarbonyl, hydrazido, acetamido, hydroxymethyl or alkanoyloxymethyl radical; and R.sub.5 and R.sub.7 are a hydrogen atom or a hydroxyl and alkanoyloxyl radical; acid addition and quaternary ammonium salts thereof and 12-chloro derivatives thereof.

摘要翻译： 具有对应于式（I）的抗肿瘤活性的化合物：其中R'1是氢原子或烷氧基，酰基，甲酰基或卤代酰基; R'2是氢原子或烷基; R'3和R'3是氢原子，羟基或烷酰氧基，并且一起是羰基，R'3和R'5一起是环氧桥或双键; R'4是氢原子或烷氧基羰基，羟甲基，烷酰氧基甲基或乙酰氨基; R'5和R'5是氢原子或羟基，烷酰氧基，乙基或2-羟乙基; R 6是氢原子或乙基，2-羟乙基或乙酰基; R1是氢原子或烷基，甲酰基或酰基; R2是氢原子或烷氧基; R3是氢原子或羟基或烷酰氧基，与R4一起是环氧桥或双键; R4是氢原子或羟基，烷酰氧基，与R5一起是环氧桥; R6是烷氧基羰基，酰肼基，乙酰氨基，羟甲基或烷酰氧基甲基; 并且R 5和R 7是氢原子或羟基和烷酰氧基; 酸加成物及其季铵盐和其12-氯衍生物。

公开(公告)号：US4347249A

公开(公告)日：1982-08-31

申请号：US167377

申请日：1980-07-09

申请人： Pierre Potier ,  Nicole Langlois ,  Yves Langlois ,  Ratremaniaina Z. Andriamialisoa ,  Pierre Mangeney

发明人： Pierre Potier ,  Nicole Langlois ,  Yves Langlois ,  Ratremaniaina Z. Andriamialisoa ,  Pierre Mangeney

IPC分类号： A61K31/475 ,  A61P35/00 ,  C07D471/20 ,  C07D519/04

CPC分类号： C07D519/04 ,  Y10S514/908

摘要： The invention relates to new chemical compounds.They are compounds corresponding to formula Ia. ##STR1## in which: R'.sub.3 represents a hydrogen atom or a hydroxy radical; R'.sub.5 represents a hydrogen atom or a hydroxy radical; or R'.sub.3 and R'.sub.5 together represent an epoxy bridge or a double bond; R".sub.5 represents a hydrogen atom or an ethyl radical; R'.sub.7 and R'.sub.8 are the same or different and represent a hydrogen atom or a methyl, hydroxymethylene, alkoxymethylene, aryloxymethylene, aminomethylene, monoalkyl or dialkyl aminomethylene, acylmethylene, arylaminomethylene, hydroxyethyl aminomethylene, alkylthiomethylene, aryloxythiomethylene or cyanomethylene radical; R.sub.1 represents a hydrogen atom or an alkyl, formyl or acyl radical: R.sub.2 represents a hydrogen atom or an alkoxy radical; R.sub.7 represents an alkanoyloxy radical, the broken line representing an optional double bond.These compounds can be used as drugs.

摘要翻译： 本发明涉及新的化合物。 它们是对应于式Ia的化合物。 （Ia）其中：R'3表示氢原子或羟基; R'5表示氢原子或羟基; 或R'3和R'5一起表示环氧桥或双键; R“5表示氢原子或乙基; R'7和R'8相同或不同，表示氢原子或甲基，羟基亚甲基，烷氧基亚甲基，芳氧基亚甲基，氨基亚甲基，单烷基或二烷基氨基亚甲基，酰亚胺基，芳基氨基亚甲基，羟乙基氨基亚甲基，烷基亚甲基，芳氧基亚甲基或氰基亚甲基。 R1表示氢原子或烷基，甲酰基或酰基：R2表示氢原子或烷氧基; R 7表示烷酰氧基，虚线表示任选的双键。 这些化合物可以用作药物。