公开(公告)号：US20220305134A1

公开(公告)日：2022-09-29

申请号：US17833077

申请日：2022-06-06

Applicant: Novartis AG

Inventor： Anthony Edward BOITANO ,  Matthew BURGER ,  Susan E. CELLITTI ,  Michael P. COOKE ,  Catrin FINNER ,  Bernhard Hubert GEIERSTANGER ,  Yunho JIN ,  Si Tuen LEE-HOEFLICH ,  HongNgoc Thi PHAM ,  Siew Ho SCHLEYER ,  Kathrin TISSOT ,  Tetsuo UNO ,  Ben WEN

IPC: A61K47/68 ,  A61K38/07 ,  A61K38/12 ,  C07K16/28

Abstract: The present invention provides antibody drug conjugates, wherein an antibody or antibody fragment that specifically binds to human cKIT is linked to a drug moiety, optionally through a linker. The present invention further provides pharmaceutical compositions comprising the antibody drug conjugates; and methods of making and using such pharmaceutical compositions for ablating hematopoietic stem cells in a patient in need thereof.

公开(公告)号：US20190321483A1

公开(公告)日：2019-10-24

申请号：US16470897

申请日：2017-12-19

Applicant: NOVARTIS AG

Inventor： Ben WEN ,  Anthony E. BOITANO ,  Matthew BURGER ,  Susan E. CELLITTI ,  Michael P. COOKE ,  Catrin FINNER ,  Bernhard Hubert GEIERSTANGER ,  Yunho JIN ,  Si Tuen LEE-HOEFLICH ,  HongNgoc Thi PHAM ,  Siew Ho SCHLEYER ,  Kathrin TISSOT ,  Tetsuo UNO

IPC: A61K47/68 ,  C07K16/28 ,  A61K38/07 ,  A61K38/12

Abstract: The present invention provides antibody drug conjugates, wherein an antibody or antibody fragment that specifically binds to human cKIT is linked to a drug moiety, optionally through a linker. The present invention further provides pharmaceutical compositions comprising the antibody drug conjugates; and methods of making and using such pharmaceutical compositions for ablating hematopoietic stem cells in a patient in need thereof.

公开(公告)号：US20210228731A1

公开(公告)日：2021-07-29

申请号：US17253584

申请日：2019-06-19

Applicant: NOVARTIS AG

Inventor： Anthony Edward BOITANO ,  Matthew T. BURGER ,  Susan E. CELLITTI ,  Michael Paul COOKE ,  Catrin FINNER ,  Bernhard Hubert GEIERSTANGER ,  Si-Tuen LEE-HOEFLICH ,  HongNgoc Thi PHAM ,  Siew Ho SCHLEYER ,  Kathrin TISSOT ,  Tetsuo UNO ,  Yongqin WAN ,  Ben WEN ,  Qiang ZHANG

IPC: A61K47/68 ,  C07K16/28 ,  A61K38/07

Abstract: The present invention provides antibody drug conjugates, wherein an antibody or antibody fragment that specifically binds to human cKIT is linked to a drug moiety, optionally through a linker. The present invention further provides pharmaceutical compositions comprising the antibody drug conjugates; and methods of making and using such pharmaceutical compositions for ablating hematopoietic stem cells in a patient in need thereof.

公开(公告)号：US20180193475A1

公开(公告)日：2018-07-12

申请号：US15329818

申请日：2015-07-27

Applicant: Novartis AG

Inventor： Tinya ABRAMS ,  Steven Bruce COHEN ,  Dylan DANIEL ,  Catrin FINNER ,  Bernhard Hubert GEIERSTANGER ,  Thomas HUBER ,  William MALLET ,  Matthew John MEYER ,  Weijia OU ,  Siew Ho SCHLEYER ,  Kathrin Ulrike TISSOT-DAGUETTE

IPC: A61K47/68 ,  A61K39/395 ,  C07K16/28 ,  A61P35/02

CPC classification number: A61K47/6803 ,  A61K39/39558 ,  A61K47/6849 ,  A61K49/00 ,  A61K51/103 ,  A61K51/1093 ,  A61K2039/505 ,  A61K2039/545 ,  A61P35/02 ,  C07K16/2803 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/77 ,  C07K2317/92

Abstract: The present invention relates to anti-cKIT antibodies, antibody fragments, antibody drug conjugates, and their uses for the treatment of cancer.

公开(公告)号：US20180125996A1

公开(公告)日：2018-05-10

申请号：US15690737

申请日：2017-08-30

Applicant: Novartis AG

Inventor： Tinya ABRAMS ,  Steven COHEN ,  Christie P. FANTON ,  Catrin FINNER ,  Thomas HUBER ,  Kathy MILLER ,  Siew Ho SCHLEYER ,  Kathrin Ulrike TISSOT-DAGUETTE

IPC: C07K16/28 ,  A61K9/00 ,  A61K9/19 ,  A61K31/537 ,  A61K45/06 ,  A61K47/12 ,  A61K47/26 ,  A61K39/00

CPC classification number: A61K47/6803 ,  A61K9/0019 ,  A61K9/19 ,  A61K31/537 ,  A61K39/39591 ,  A61K45/06 ,  A61K47/12 ,  A61K47/26 ,  A61K47/6801 ,  A61K47/6849 ,  A61K47/6855 ,  A61K47/6857 ,  A61K47/6865 ,  A61K47/6867 ,  A61K47/6889 ,  A61K47/6921 ,  A61K49/00 ,  A61K51/103 ,  A61K51/1093 ,  A61K2039/505 ,  A61P35/00 ,  C07K16/2803 ,  C07K16/2863 ,  C07K16/32 ,  C07K2317/14 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/30 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/732 ,  C07K2317/76 ,  C07K2317/77 ,  C07K2317/92 ,  G01N33/53 ,  G01N33/574 ,  G01N33/57492

Abstract: The present invention relates to anti-cKIT antibodies, antibody fragments, antibody drug conjugates, and their uses for the treatment of cancer.