公开(公告)号：US20190321483A1

公开(公告)日：2019-10-24

申请号：US16470897

申请日：2017-12-19

Applicant: NOVARTIS AG

Inventor： Ben WEN ,  Anthony E. BOITANO ,  Matthew BURGER ,  Susan E. CELLITTI ,  Michael P. COOKE ,  Catrin FINNER ,  Bernhard Hubert GEIERSTANGER ,  Yunho JIN ,  Si Tuen LEE-HOEFLICH ,  HongNgoc Thi PHAM ,  Siew Ho SCHLEYER ,  Kathrin TISSOT ,  Tetsuo UNO

IPC: A61K47/68 ,  C07K16/28 ,  A61K38/07 ,  A61K38/12

Abstract: The present invention provides antibody drug conjugates, wherein an antibody or antibody fragment that specifically binds to human cKIT is linked to a drug moiety, optionally through a linker. The present invention further provides pharmaceutical compositions comprising the antibody drug conjugates; and methods of making and using such pharmaceutical compositions for ablating hematopoietic stem cells in a patient in need thereof.

公开(公告)号：US20230053449A1

公开(公告)日：2023-02-23

申请号：US17289058

申请日：2019-10-30

Applicant: NOVARTIS AG

Inventor： Lisa BARNETT ,  Steven BENDER ,  Alex Cortez ,  Sarah COX ,  Jonathan DEANE ,  Scott Martin GLASER ,  Ben WEN ,  Tom Yao-Hsiang WU

IPC: A61K47/68 ,  C07K16/28 ,  A61P35/00

Abstract: Provided herein are antibodies to DC-SIGN, conjugates of DC-SiGN antibodies, and DC-SiGN antibody fusion proteins and the use of such antibodies, conjugates, and fusion proteins for the treatment of diseases such as cancer.

公开(公告)号：US20210228731A1

公开(公告)日：2021-07-29

申请号：US17253584

申请日：2019-06-19

Applicant: NOVARTIS AG

Inventor： Anthony Edward BOITANO ,  Matthew T. BURGER ,  Susan E. CELLITTI ,  Michael Paul COOKE ,  Catrin FINNER ,  Bernhard Hubert GEIERSTANGER ,  Si-Tuen LEE-HOEFLICH ,  HongNgoc Thi PHAM ,  Siew Ho SCHLEYER ,  Kathrin TISSOT ,  Tetsuo UNO ,  Yongqin WAN ,  Ben WEN ,  Qiang ZHANG

IPC: A61K47/68 ,  C07K16/28 ,  A61K38/07

Abstract: The present invention provides antibody drug conjugates, wherein an antibody or antibody fragment that specifically binds to human cKIT is linked to a drug moiety, optionally through a linker. The present invention further provides pharmaceutical compositions comprising the antibody drug conjugates; and methods of making and using such pharmaceutical compositions for ablating hematopoietic stem cells in a patient in need thereof.

公开(公告)号：US20220305134A1

公开(公告)日：2022-09-29

申请号：US17833077

申请日：2022-06-06

Applicant: Novartis AG

Inventor： Anthony Edward BOITANO ,  Matthew BURGER ,  Susan E. CELLITTI ,  Michael P. COOKE ,  Catrin FINNER ,  Bernhard Hubert GEIERSTANGER ,  Yunho JIN ,  Si Tuen LEE-HOEFLICH ,  HongNgoc Thi PHAM ,  Siew Ho SCHLEYER ,  Kathrin TISSOT ,  Tetsuo UNO ,  Ben WEN

IPC: A61K47/68 ,  A61K38/07 ,  A61K38/12 ,  C07K16/28

Abstract: The present invention provides antibody drug conjugates, wherein an antibody or antibody fragment that specifically binds to human cKIT is linked to a drug moiety, optionally through a linker. The present invention further provides pharmaceutical compositions comprising the antibody drug conjugates; and methods of making and using such pharmaceutical compositions for ablating hematopoietic stem cells in a patient in need thereof.

公开(公告)号：US20210170043A1

公开(公告)日：2021-06-10

申请号：US16669291

申请日：2019-10-30

Applicant: NOVARTIS AG ,  ADURO BIOTECH, INC.

Inventor： Lisa BARNETT ,  Steven BENDER ,  Charles Y. CHO ,  Sarah COX ,  Jonathan Deane ,  Scott Martin GLASER ,  Xueshi Hao ,  Shailaja KASIBHATLA ,  Weijia OU ,  Tetsuo UNO ,  Yongqin WAN ,  Ben WEN ,  Tom Yao-Hsiang WU

IPC: A61K47/68 ,  C07K16/28 ,  A61K31/688 ,  A61P35/00

Abstract: Provided herein are immunoconjugates comprising an anti-DC-SIGN antibody conjugated to a STING agonist. Also disclosed are methods of making the immunoconjugates and methods of treating cancer using the immunoconjugates.