公开(公告)号：US11802152B2

公开(公告)日：2023-10-31

申请号：US17539335

申请日：2021-12-01

Applicant: Novartis AG

Inventor： Brian Boettcher ,  Shari Lynn Caplan ,  Regis Cebe ,  Guochun Li ,  John A. Taraszka ,  Fangmin Xu ,  David Langdon Yowe

IPC: C07K16/28 ,  A61P3/00 ,  A61K39/00

CPC classification number: C07K16/28 ,  A61P3/00 ,  A61K39/001107 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/55 ,  C07K2317/92 ,  C07K2317/94 ,  C07K2318/00

Abstract: The present invention relates to monoclonal antibodies and antigen-binding fragments thereof that bind to human β-klotho, and pharmaceutical compositions and methods of treatment comprising the same.

公开(公告)号：US11236159B2

公开(公告)日：2022-02-01

申请号：US15749775

申请日：2016-08-02

Applicant: Novartis AG

Inventor： Brian Boettcher ,  Shari Lynn Caplan ,  Regis Cebe ,  Guochun Li ,  John A. Taraszka ,  Fangmin Xu ,  David Langdon Yowe

IPC: C07K16/28 ,  A61P3/00 ,  A61K39/00

Abstract: The present invention relates to monoclonal antibodies and antigen-binding fragments thereof that bind to human β-klotho, and pharmaceutical compositions and methods of treatment comprising the same.