公开(公告)号：US20240299574A1

公开(公告)日：2024-09-12

申请号：US18672871

申请日：2024-05-23

Applicant: Novartis AG

Inventor： Matthew Burger ,  Joseph A. D'Alessio ,  Tony Fleming ,  Vivek Rauniyar ,  Eusebio Manchado Robles

IPC: A61K47/68 ,  A61K31/4745 ,  A61K45/06 ,  A61P35/00 ,  C07K16/18

CPC classification number: A61K47/6803 ,  A61K31/4745 ,  A61P35/00 ,  C07K16/18 ,  A61K45/06

Abstract: This application discloses anti-PMEL17 antibodies, antigen binding fragments thereof, and antibody drug conjugates of said antibodies or antigen binding fragments conjugated to a GNAQ/GNA11 inhibitor. The invention also relates to methods of treating or preventing cancer using the antibodies, antigen binding fragments, and antibody drug conjugates. Also disclosed herein are methods of making the antibodies, antigen binding fragments, and antibody drug conjugates, and methods of using the antibodies and antigen binding fragments as diagnostic reagents.