公开(公告)号：US10188649B2

公开(公告)日：2019-01-29

申请号：US15672568

申请日：2017-08-09

Applicant: Novartis AG

Inventor： Jeffrey T. Bagdanoff ,  Yu Ding ,  Wooseok Han ,  Zilin Huang ,  Qun Jiang ,  Xianming Jin ,  Xiang Kou ,  Patrick Lee ,  Mika Lindvall ,  Zhongcheng Min ,  Yue Pan ,  Sabina Pecchi ,  Keith Bruce Pfister ,  Daniel Poon ,  Vivek Rauniyar ,  Xiaojing Michael Wang ,  Qiong Zhang ,  Jianguang Zhou ,  Shejin Zhu

IPC: C07D241/20 ,  A61K31/4965 ,  A61K31/497 ,  A61K31/4436 ,  A61K31/4439 ,  A61K31/4545 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/5383 ,  A61K31/553 ,  A61K45/06 ,  C07D401/04 ,  C07D405/04 ,  C07D405/14 ,  C07D409/04 ,  C07D413/14 ,  C07D498/04 ,  C07D213/73 ,  C07D401/06 ,  C07D401/12 ,  C07D403/06 ,  A61K31/44 ,  A61K31/4433 ,  A61K31/5355

Abstract: The present invention provides a compound of Formula (I) or a salt thereof; and therapeutic uses of these compounds. The present invention further provides pharmaceutical compositions comprising these compounds, and compositions comprising these compounds with a therapeutic co-agent.

公开(公告)号：US11779649B2

公开(公告)日：2023-10-10

申请号：US16718866

申请日：2019-12-18

Applicant: Novartis AG

Inventor： Matthew Burger ,  Joseph Anthony D'Alessio ,  Tony Fleming ,  Vivek Rauniyar ,  Eusebio Manchado Robles ,  Christian Kunz ,  Markus Waldhuber

IPC: A61K47/68 ,  A61P35/00 ,  A61K31/4745 ,  C07K16/18 ,  A61K45/06

CPC classification number: A61K47/6803 ,  A61K31/4745 ,  A61P35/00 ,  C07K16/18 ,  A61K45/06

Abstract: This application discloses anti-PMEL17 antibodies, antigen binding fragments thereof, and antibody drug conjugates comprising antibodies or antigen binding fragments conjugated to a GNAQ/GNA11 inhibitor. The application also discloses methods of treating or preventing cancer using the antibodies, antigen binding fragments, and antibody drug conjugates. Also disclosed herein are methods of making the antibodies, antigen binding fragments, and antibody drug conjugates, and methods of using the antibodies and antigen binding fragments as diagnostic reagents.

公开(公告)号：US12129246B1

公开(公告)日：2024-10-29

申请号：US18589841

申请日：2024-02-28

Applicant: Novartis AG

Inventor： Daniela Angst ,  Philippe Bolduc ,  Matthew William Carson ,  Atwood Kim Cheung ,  Véronique Darsigny ,  Xiang Gao ,  Viktor Hornak ,  Keith Jendza ,  Rajesh Karki ,  Ajay Kumar Lal ,  Gang Liu ,  Justin Yik Ching Mao ,  Jeffrey M. McKenna ,  Erik Meredith ,  Muneto Mogi ,  Vivek Rauniyar ,  Liansheng Su ,  Ritesh Tichkule ,  Shuangxi Wang ,  Chun Zhang ,  Liang Zhao ,  Rui Zheng

IPC: C07D403/14 ,  A61K31/517 ,  A61K31/55 ,  A61K45/06 ,  C07D239/95 ,  C07D401/12 ,  C07D401/14

CPC classification number: C07D403/14 ,  A61K31/517 ,  A61K31/55 ,  A61K45/06 ,  C07D239/95 ,  C07D401/12 ,  C07D401/14

Abstract: The disclosure relates to a compound of Formula (I):




or a pharmaceutically acceptable salt thereof wherein A, Ra to Rd, and R4 to R7, are as described herein, as well as compositions and methods of using such compounds.

公开(公告)号：US20240299574A1

公开(公告)日：2024-09-12

申请号：US18672871

申请日：2024-05-23

Applicant: Novartis AG

Inventor： Matthew Burger ,  Joseph A. D'Alessio ,  Tony Fleming ,  Vivek Rauniyar ,  Eusebio Manchado Robles

IPC: A61K47/68 ,  A61K31/4745 ,  A61K45/06 ,  A61P35/00 ,  C07K16/18

CPC classification number: A61K47/6803 ,  A61K31/4745 ,  A61P35/00 ,  C07K16/18 ,  A61K45/06

Abstract: This application discloses anti-PMEL17 antibodies, antigen binding fragments thereof, and antibody drug conjugates of said antibodies or antigen binding fragments conjugated to a GNAQ/GNA11 inhibitor. The invention also relates to methods of treating or preventing cancer using the antibodies, antigen binding fragments, and antibody drug conjugates. Also disclosed herein are methods of making the antibodies, antigen binding fragments, and antibody drug conjugates, and methods of using the antibodies and antigen binding fragments as diagnostic reagents.

公开(公告)号：US20240189439A1

公开(公告)日：2024-06-13

申请号：US18454457

申请日：2023-08-23

Applicant: Novartis AG

Inventor： Matthew Burger ,  Joseph Anthony D'Alessio ,  Tony Fleming ,  Vivek Rauniyar ,  Eusebio Manchado Robles ,  Christian Kunz ,  Markus Waldhuber

IPC: A61K47/68 ,  A61K31/4745 ,  A61P35/00 ,  C07K16/18

CPC classification number: A61K47/6803 ,  A61K31/4745 ,  A61P35/00 ,  C07K16/18 ,  A61K45/06

Abstract: This application discloses anti-PMEL17 antibodies, antigen binding fragments thereof, and antibody drug conjugates of said antibodies or antigen binding fragments conjugated to a GNAQ/GNA11 inhibitor. The invention also relates to methods of treating or preventing cancer using the antibodies, antigen binding fragments, and antibody drug conjugates. Also disclosed herein are methods of making the antibodies, antigen binding fragments, and antibody drug conjugates, and methods of using the antibodies and antigen binding fragments as diagnostic reagents.

公开(公告)号：US10660888B2

公开(公告)日：2020-05-26

申请号：US16210968

申请日：2018-12-05

Applicant: Novartis AG

Inventor： Jeffrey T. Bagdanoff ,  Yu Ding ,  Wooseok Han ,  Zilin Huang ,  Qun Jiang ,  Xianming Jin ,  Xiang Kou ,  Patrick Lee ,  Mika Lindvall ,  Zhongcheng Min ,  Yue Pan ,  Sabina Pecchi ,  Keith Bruce Pfister ,  Daniel Poon ,  Vivek Rauniyar ,  Xiaojing Michael Wang ,  Qiong Zhang ,  Jianguang Zhou ,  Shejin Zhu

IPC: A61K31/497 ,  C07D213/73 ,  C07D401/06 ,  C07D401/12 ,  C07D403/06 ,  A61K31/4436 ,  A61K31/4439 ,  A61K31/4545 ,  A61K31/4965 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/5383 ,  A61K31/553 ,  A61K45/06 ,  C07D241/20 ,  C07D401/04 ,  C07D405/04 ,  C07D405/14 ,  C07D409/04 ,  C07D413/14 ,  C07D498/04 ,  A61K31/44 ,  A61K31/4433 ,  A61K31/5355

Abstract: The present invention provides a compound of Formula (I) or a salt thereof; and therapeutic uses of these compounds. The present invention further provides pharmaceutical compositions comprising these compounds, and compositions comprising these compounds with a therapeutic co-agent.

公开(公告)号：US10377770B2

公开(公告)日：2019-08-13

申请号：US16062680

申请日：2016-12-15

Applicant: Novartis AG

Inventor： Robert John Aversa ,  Matthew T. Burger ,  Michael Patrick Dillon ,  Thomas A. Dineen, Jr. ,  Rajesh Karki ,  Savithri Ramurthy ,  Vivek Rauniyar ,  Richard Robinson ,  Patrick James Sarver

IPC: C07D487/04 ,  C07D491/04 ,  C07D498/04 ,  A61P35/00 ,  C07D491/044

Abstract: The present invention provides compounds of Formula (A): (I) as described herein, and salts thereof, and therapeutic uses of these compounds for treatment of disorders associated with Raf kinase activity. The invention further provides pharmaceutical compositions comprising these compounds, and compositions comprising these compounds and a therapeutic co-agent, and methods of using the compositions and combinations to treat conditions including cancers.

公开(公告)号：US10167279B2

公开(公告)日：2019-01-01

申请号：US15510609

申请日：2015-09-11

Applicant: NOVARTIS AG

Inventor： Robert John Aversa ,  Matthew T. Burger ,  Michael Patrick Dillon ,  Thomas A. Dineen, Jr. ,  Yan Lou ,  Gisele A. Nishiguchi ,  Savithri Ramurthy ,  Alice C. Rico ,  Vivek Rauniyar ,  Martin Sendzik ,  Sharadha Subramanian ,  Lina Quattrocchio Setti ,  Benjamin R. Taft ,  Huw Rowland Tanner ,  Lifeng Wan

IPC: C07D405/14 ,  C07D405/12 ,  C07D305/06 ,  A61P35/00 ,  C07D413/14

Abstract: The present invention provides compounds of Formula (I) and (II) as described herein, and salts thereof, and therapeutic uses of these compounds for treatment of disorders associated with Raf kinase activity. The invention further provides pharmaceutical compositions comprising these compounds, and compositions comprising these compounds and a therapeutic co-agent.