公开(公告)号：US10683287B2

公开(公告)日：2020-06-16

申请号：US16378887

申请日：2019-04-09

Applicant: Novartis AG

Inventor： Sangamesh Badiger ,  Murali Chebrolu ,  Konstanze Hurth ,  Sebastien Jacquier ,  Rainer Martin Lueoend ,  Rainer Machauer ,  Heinrich Rueeger ,  Marina Tintelnot-Blomley ,  Siem Jacob Veenstra ,  Markus Voegtle

IPC: C07D413/04 ,  C07D413/14 ,  C07D471/04 ,  C07D487/04 ,  A61K31/5377 ,  C07B59/00

Abstract: The invention relates to novel heterocyclic compounds of the formula in which all of the variables are as defined in the specification, pharmaceutical compositions thereof, combinations thereof, and their use as medicaments, particularly for the treatment of Alzheimer's Disease or diabetes via inhibition of BACE-1 or BACE-2.

公开(公告)号：US20200048236A1

公开(公告)日：2020-02-13

申请号：US16378887

申请日：2019-04-09

Applicant: Novartis AG

Inventor： Sangamesh Badiger ,  Murali Chebrolu ,  Konstanze Hurth ,  Sebastien Jacquier ,  Rainer Martin Lueoend ,  Rainer Machauer ,  Heinrich Rueeger ,  Marina Tintelnot-Blomley ,  Siem Jacob Veenstra ,  Markus Voegtle

IPC: C07D413/14 ,  C07D471/04 ,  A61K31/5377 ,  C07D487/04

Abstract: The invention relates to novel heterocyclic compounds of the formula in which all of the variables are as defined in the specification, pharmaceutical compositions thereof, combinations thereof, and their use as medicaments, particularly for the treatment of Alzheimer's Disease or diabetes via inhibition of BACE-1 or BACE-2.

公开(公告)号：US10301296B2

公开(公告)日：2019-05-28

申请号：US16020212

申请日：2018-06-27

Applicant: Novartis AG

Inventor： Sangamesh Badiger ,  Murali Chebrolu ,  Konstanze Hurth ,  Sebastien Jacquier ,  Rainer Martin Lueoend ,  Rainer Machauer ,  Heinrich Rueeger ,  Marina Tintelnot-Blomley ,  Siem Jacob Veenstra ,  Markus Voegtle

IPC: C07D413/14 ,  C07D471/04 ,  C07D487/04 ,  A61K31/5377 ,  C07B59/00

Abstract: The invention relates to novel heterocyclic compounds of the formula in which all of the variables are as defined in the specification, pharmaceutical compositions thereof, combinations thereof, and their use as medicaments, particularly for the treatment of Alzheimer's Disease or diabetes via inhibition of BACE-1 or BACE-2.

公开(公告)号：US20190062319A1

公开(公告)日：2019-02-28

申请号：US16020212

申请日：2018-06-27

Applicant: Novartis AG

Inventor： Sangamesh Badiger ,  Murali Chebrolu ,  Konstanze Hurth ,  Sebastien Jacquier ,  Rainer Martin Lueoend ,  Rainer Machauer ,  Heinrich Rueeger ,  Marina Tintelnot-Blomley ,  Siem Jacob Veenstra ,  Markus Voegtle

IPC: C07D413/14 ,  C07D487/04 ,  C07D471/04 ,  A61K31/5377 ,  C07B59/00

Abstract: The invention relates to novel heterocyclic compounds of the formula in which all of the variables are as defined in the specification, pharmaceutical compositions thereof, combinations thereof, and their use as medicaments, particularly for the treatment of Alzheimer's Disease or diabetes via inhibition of BACE-1 or BACE-2.

公开(公告)号：US10035794B2

公开(公告)日：2018-07-31

申请号：US15385147

申请日：2016-12-20

Applicant: NOVARTIS AG

Inventor： Sangamesh Badiger ,  Murali Chebrolu ,  Konstanze Hurth ,  Sebastien Jacquier ,  Rainer Martin Lueoend ,  Rainer Machauer ,  Heinrich Rueeger ,  Marina Tintelnot-Blomley ,  Siem Jacob Veenstra ,  Markus Voegtle

IPC: C07D413/14 ,  C07D487/04 ,  C07D471/04 ,  A61K31/5377 ,  C07B59/00

Abstract: The invention relates to novel heterocyclic compounds of the formula in which all of the variables are as defined in the specification, pharmaceutical compositions thereof, combinations thereof, and their use as medicaments, particularly for the treatment of Alzheimer's Disease or diabetes via inhibition of BACE-1 or BACE-2.