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公开(公告)号:US11685776B2
公开(公告)日:2023-06-27
申请号:US16483185
申请日:2018-03-01
Applicant: Novartis AG
Inventor: Regis Cebe , Sebastien Irigaray , Darko Skegro
CPC classification number: C07K16/244 , C07K16/2863 , C07K2317/31 , C07K2317/50 , C07K2317/522 , C07K2317/55 , C07K2317/60 , C07K2317/66
Abstract: The present invention provides heterodimeric antibodies and fragments thereof and methods for their preparation, wherein the pairing of heavy and light chains has been improved. Interface residues were mutated such that each light chain strongly favoured its cognate heavy chain when two different heavy chains and two different light chains were co-transfected and co-expressed in the same cell to assemble a functional, heterodimeric antibody or fragment thereof.