公开(公告)号：US20220324831A1

公开(公告)日：2022-10-13

申请号：US17753645

申请日：2020-09-07

Applicant: OLON S.P.A.

Inventor： Valentina Grande ,  Alessia Manfredi ,  Jacopo Bonanomi ,  Gabriele Ferretti ,  Barbara Novo ,  Mara Sada ,  Giorgio Bertolini

IPC: C07D401/04

Abstract: The present invention relates to a novel non-solvated crystalline form of apalutamide in pure, stable form, and the process for the preparation thereof.

公开(公告)号：US20210206742A1

公开(公告)日：2021-07-08

申请号：US17059551

申请日：2019-05-27

Applicant: OLON S.P.A.

Inventor： Valentina Grande ,  Gabriele Ferretti ,  Barbara Novo

IPC: C07D401/04 ,  C07C327/24 ,  C07C237/30 ,  C07F7/18

Abstract: The present invention relates to a process for the preparation of Apalutamide of formula (A) Apalutamide is a latest-generation androgen receptor inhibitor, used to treat non-metastatic castration-resistant prostate cancer.

公开(公告)号：US11820752B2

公开(公告)日：2023-11-21

申请号：US17059551

申请日：2019-05-27

Applicant: OLON S.P.A.

Inventor： Valentina Grande ,  Gabriele Ferretti ,  Barbara Novo

IPC: C07D401/04 ,  C07C237/30 ,  C07C327/24 ,  C07F7/18

CPC classification number: C07D401/04 ,  C07C237/30 ,  C07C327/24 ,  C07F7/1896 ,  C07C2601/04 ,  C07C2601/16

Abstract: The present invention relates to a process for the preparation of Apalutamide of formula (A) Apalutamide is a latest-generation androgen receptor inhibitor, used to treat non-metastatic castration-resistant prostate cancer.

公开(公告)号：US20220153718A1

公开(公告)日：2022-05-19

申请号：US17438948

申请日：2020-03-09

Applicant: OLON S.P.A.

Inventor： Valentina Grande ,  Barbara Novo ,  Mara SADA ,  Gabriele Ferretti ,  Alessia Manfredi

IPC: C07D401/04

Abstract: The present invention relates to a process for the preparation of apalutamide in stable amorphous form. The invention also relates to a novel intermediate crystalline form, called form X, which gives rise to said amorphous form, and a process for obtaining said form X.