公开(公告)号：US20240142471A1

公开(公告)日：2024-05-02

申请号：US18278931

申请日：2022-02-09

Applicant: OSAKA UNIVERSITY

Inventor： Masuo KONDOH ,  Keisuke TACHIBANA ,  Ryuichi HIRAYAMA

IPC: G01N33/68

CPC classification number: G01N33/6896 ,  G01N2333/705 ,  G01N2800/2821 ,  G01N2800/2835 ,  G01N2800/285 ,  G01N2800/301 ,  G01N2800/304

Abstract: Provided is a means for detecting a subject with mild cognitive impairment or assisting in the detection thereof.
A biomarker for testing for mild cognitive impairment, comprising Claudin-5.

公开(公告)号：US20230113556A1

公开(公告)日：2023-04-13

申请号：US17907323

申请日：2021-03-26

Applicant: NATIONAL CEREBRAL AND CARDIOVASCULAR CENTER ,  OSAKA UNIVERSITY

Inventor： Mariko SHIBA ,  Tsuyoshi YAMAMOTO ,  Fumito WADA ,  Tadayuki KOBAYASHI ,  Keisuke TACHIBANA ,  Satoshi OBIKA

IPC: C12N15/113 ,  A61P3/06

Abstract: The present invention provides an antisense oligomer having the base sequence depicted in SEQ ID NO: 26, an antisense oligomer having a base sequence resulting from substitution, deletion, insertion, or addition of 1 to 6 bases in the base sequence depicted in SEQ ID NO: 26, a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable hydrate thereof, an oligonucleotide conjugate in which the antisense oligomer is bound with a molecule capable of binding to an asialoglycoprotein receptor, and a pharmaceutical composition containing the same.