Patent search ap:("OSAKA UNIVERSITY") AND inv:"Takefumi DOI" Page 1

1.

发明申请
Claudin 5 ANTIBODY, AND MEDICINE CONTAINING SAID ANTIBODY 审中-公开

公开(公告)号：US20200223915A1

公开(公告)日：2020-07-16

申请号：US16467751

申请日：2017-12-04

Applicant: OSAKA UNIVERSITY

Inventor： Yoshiaki OKADA , Masuo KONDOH , Yosuke HASHIMOTO , Keisuke SHIRAKURA , Takefumi DOI , Kiyohito YAGI , Hiroyuki TAKEDA , Tatsuya SAWASAKI

IPC: C07K16/28 , A61K39/395

Abstract: Provided is a novel technique for controlling the blood-brain barrier. An antibody whose epitope is a region within an extracellular domain of Claudin 5 protein.

2.

发明申请
METHOD FOR PRODUCING SUBSTANCE WITH MODIFIED CARBON ALLOTROPE SURFACE, METHOD FOR PRODUCING SUBSTANCE WITH CARBON ALLOTROPE SURFACE INTO WHICH FUNCTIONAL GROUP IS INTRODUCED, METHOD FOR PRODUCING GRID FOR CRYO-ELECTRON MICROSCOPY, ORGANIC SUBSTANCE, AND GRID FOR CRYO-ELECTRON MICROSCOPY 有权

公开(公告)号：US20220204346A1

公开(公告)日：2022-06-30

申请号：US17441971

申请日：2020-03-27

Applicant: OSAKA UNIVERSITY

Inventor： Tsuyoshi INOUE , Haruyasu ASAHARA , Kei OHKUBO , Kenji IWASAKI , Naoyuki MIYAZAKI , Mika HIROSE , Atsushi NAKAGAWA , Junichi TAKAGI , Takefumi DOI , Hiroaki ADACHI

IPC: C01B32/156 , C01B32/05 , C01B32/168 , C01B32/194 , H01J37/20

Abstract: The present invention provides a method for producing a substance with a modified carbon allotrope surface that can suppress or prevent uneven distribution, uneven orientation, and the like of a structural analysis target substance in a structural analysis by cryo-electron microscopy. A method for producing a substance with a modified carbon allotrope surface of the present invention includes: the step of surface-treating by reacting a carbon allotrope surface with a halogen oxide radical, wherein the carbon allotrope surface is modified by the surface-treating.

3.

发明申请
ANTI-CLDN-5 ANTIBODY, AND DRUG CONTAINING SAID ANTIBODY 审中-公开

公开(公告)号：US20200148765A1

公开(公告)日：2020-05-14

申请号：US16611678

申请日：2018-04-26

Applicant: OSAKA UNIVERSITY , NATIONAL UNIVERSITY CORPORATION EHIME UNIVERSITY , FUJIFILM Wako Pure Chemical Corporation

Inventor： Masuo KONDOH , Kiyohito YAGI , Takefumi DOI , Yoshiaki OKADA , Yosuke HASHIMOTO , Tatsuya SAWASAKI , Hiroyuki TAKEDA , Kohki ENDO , Maki TAMURA

IPC: C07K16/28

Abstract: An object of the present invention is to provide a novel molecule which has high specificity to CLDN-5 and recognizes an extracellular domain of CLDN-5. The object is achieved by an antibody which specifically recognizes a three-dimensional structure or a primary structure of an extracellular domain of a Claudin-5 protein.

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