公开(公告)号：US20200223915A1

公开(公告)日：2020-07-16

申请号：US16467751

申请日：2017-12-04

Applicant: OSAKA UNIVERSITY

Inventor： Yoshiaki OKADA ,  Masuo KONDOH ,  Yosuke HASHIMOTO ,  Keisuke SHIRAKURA ,  Takefumi DOI ,  Kiyohito YAGI ,  Hiroyuki TAKEDA ,  Tatsuya SAWASAKI

IPC: C07K16/28 ,  A61K39/395

Abstract: Provided is a novel technique for controlling the blood-brain barrier. An antibody whose epitope is a region within an extracellular domain of Claudin 5 protein.

公开(公告)号：US20200148765A1

公开(公告)日：2020-05-14

申请号：US16611678

申请日：2018-04-26

Applicant: OSAKA UNIVERSITY ,  NATIONAL UNIVERSITY CORPORATION EHIME UNIVERSITY ,  FUJIFILM Wako Pure Chemical Corporation

Inventor： Masuo KONDOH ,  Kiyohito YAGI ,  Takefumi DOI ,  Yoshiaki OKADA ,  Yosuke HASHIMOTO ,  Tatsuya SAWASAKI ,  Hiroyuki TAKEDA ,  Kohki ENDO ,  Maki TAMURA

IPC: C07K16/28

Abstract: An object of the present invention is to provide a novel molecule which has high specificity to CLDN-5 and recognizes an extracellular domain of CLDN-5. The object is achieved by an antibody which specifically recognizes a three-dimensional structure or a primary structure of an extracellular domain of a Claudin-5 protein.