公开(公告)号：US20240124496A1

公开(公告)日：2024-04-18

申请号：US18551674

申请日：2022-03-24

Applicant: OSAKA UNIVERSITY

Inventor： Yoshifumi SHIRAKAMI ,  Kazuko KANEDA ,  Yuichiro KADONAGA ,  Tadashi WATABE ,  Atsushi TOYOSHIMA ,  Koichi FUKASE ,  Atsushi SHINOHARA ,  Toshio YAMANAKA ,  Yutaka KONDOH

IPC: C07F5/02 ,  B01J31/22 ,  B01J31/24 ,  C07B59/00 ,  C07C227/16 ,  C07F13/00

CPC classification number: C07F5/025 ,  B01J31/2295 ,  B01J31/2409 ,  C07B59/00 ,  C07C227/16 ,  C07F13/00 ,  B01J2231/40 ,  B01J2531/004 ,  B01J2531/824 ,  B01J2531/842 ,  C07B2200/05

Abstract: The invention provides a method for producing radiolabeled tyrosine derivatives with good purity and stability, by a safe method suitable for industrial production of pharmaceuticals. The invention relates to a method for producing Compound (5) and Radiolabeled Compound (6) as follows:




wherein each symbol is as defined in the description.