公开(公告)号：US20240199521A1

公开(公告)日：2024-06-20

申请号：US18275291

申请日：2022-01-19

Applicant: FUDAN UNIVERSITY

Inventor： Shengming MA ,  Weifeng ZHENG ,  Hui QIAN

IPC: C07C51/12 ,  B01J31/02 ,  B01J31/22 ,  B01J31/24 ,  C07C59/52

CPC classification number: C07C51/12 ,  B01J31/0259 ,  B01J31/2282 ,  B01J31/2428 ,  C07C59/52 ,  B01J2531/004 ,  B01J2531/0205 ,  B01J2531/824

Abstract: Disclosed in the present invention is a preparation method for a tetra-substituted allenoic acid compound based on a palladium catalytic system, that is, a highly optically active allenoic acid compound having axial chirality is directly constructed in one step by reacting tertiary propargyl alcohol, carbon monoxide and water in an organic solvent under the action of a palladium catalyst, a chiral bisphosphine ligand, an organophosphoric acid, and an organic additive, and the theoretical yield can reach 100%. The method of the present invention is simple to operate, the raw materials and reagents are readily available, the reaction conditions are mild, the substrate universality is wide, the functional group compatibility is good, the reaction has high enantioselectivity (77%˜96% ee), and the reaction is well compatible with complex natural products or substrates of a drug molecular skeleton. The highly optically active allenoic acid compound obtained by the present invention can be used as an important intermediate for constructing a γ-butyrolactone compound containing a tetra-substituted chiral quaternary carbon center, tetra-substituted allenol, tetra-substituted allenal, tetra-substituted allenyl ketone, tetra-substituted allenami de and other compounds.

公开(公告)号：US20240124496A1

公开(公告)日：2024-04-18

申请号：US18551674

申请日：2022-03-24

Applicant: OSAKA UNIVERSITY

Inventor： Yoshifumi SHIRAKAMI ,  Kazuko KANEDA ,  Yuichiro KADONAGA ,  Tadashi WATABE ,  Atsushi TOYOSHIMA ,  Koichi FUKASE ,  Atsushi SHINOHARA ,  Toshio YAMANAKA ,  Yutaka KONDOH

IPC: C07F5/02 ,  B01J31/22 ,  B01J31/24 ,  C07B59/00 ,  C07C227/16 ,  C07F13/00

CPC classification number: C07F5/025 ,  B01J31/2295 ,  B01J31/2409 ,  C07B59/00 ,  C07C227/16 ,  C07F13/00 ,  B01J2231/40 ,  B01J2531/004 ,  B01J2531/824 ,  B01J2531/842 ,  C07B2200/05

Abstract: The invention provides a method for producing radiolabeled tyrosine derivatives with good purity and stability, by a safe method suitable for industrial production of pharmaceuticals. The invention relates to a method for producing Compound (5) and Radiolabeled Compound (6) as follows:




wherein each symbol is as defined in the description.

公开(公告)号：US11712688B2

公开(公告)日：2023-08-01

申请号：US17215095

申请日：2021-03-29

Applicant: EVONIK OPERATIONS GMBH

Inventor： Ji Yang ,  Ralf Jackstell ,  Matthias Beller ,  Robert Franke

IPC: B01J31/24 ,  B01J31/18 ,  C07F9/50

CPC classification number: B01J31/2409 ,  B01J31/1815 ,  C07F9/5045 ,  B01J2231/321 ,  B01J2531/004 ,  B01J2531/828

Abstract: Platinum complexes having benzyl-based diphosphine ligands for the catalysis of the alkoxycarbonylation of ethylenically unsaturated compounds.

公开(公告)号：US20190185593A1

公开(公告)日：2019-06-20

申请号：US16325261

申请日：2017-08-28

Applicant: JXTG NIPPON OIL & ENERGY CORPORATION

Inventor： Fuyuki AIDA ,  Kazuo TAGAWA

IPC: C08F4/70 ,  B01J31/22 ,  C08F10/02 ,  C08F210/16

CPC classification number: C08F4/7042 ,  B01J31/22 ,  B01J2231/20 ,  B01J2531/004 ,  B01J2531/005 ,  B01J2531/0241 ,  B01J2531/842 ,  C08F4/70 ,  C08F10/00 ,  C08F10/02 ,  C08F210/16

Abstract: A method for producing an oligomer, the method comprising a step of oligomerizing a polymerizable monomer comprising an olefin in the presence of a catalyst comprising an iron complex represented by the following Formula (1) and trialkylaluminum: [In Formula (1), R represents a hydrocarbyl group having 1 to 6 carbon atoms or an aromatic group having 6 to 12 carbon atoms, a plurality of R in the same molecule may be the same or different, R′ represents a free radical having an oxygen atom and/or a nitrogen atom, a plurality of R′ in the same molecule may be the same or different, and Y represents a chlorine atom or a bromine atom].

公开(公告)号：US10189760B2

公开(公告)日：2019-01-29

申请号：US15319370

申请日：2015-10-09

Applicant: ZHEJIANG HUAHAI PHARMACEUTICAL CO., LTD. ,  SHANGHAI SYNCORES TECHNOLOGIES INC. LTD.

Inventor： Jian Hong ,  Yusheng Wang ,  Boyu Wang ,  Luning Huang ,  Eric Gu

IPC: C07C229/00 ,  C07C29/153 ,  B01J27/18 ,  C07C25/13 ,  C07D487/04 ,  C07C29/151

CPC classification number: C07C29/153 ,  B01J27/18 ,  B01J2231/44 ,  B01J2531/004 ,  C07C25/13 ,  C07C29/1514 ,  C07C227/32 ,  C07C229/34 ,  C07C269/04 ,  C07C271/22 ,  C07D487/04

Abstract: Disclosed is a method for synthesizing a sitagliptin intermediate, the method comprising: in the presence of hydrogen and a transition metal catalyst having a chiral phosphine ligand, subjecting a compound of formula II to an asymmetric reductive amination with ammonia or ammonium salt in a proper organic solvent under the condition of adding an acidic additive to produce a compound of formula I, wherein, an R- or S-configuration of a stereocenter is represented by *; the compound of formula I of R configuration can be used to prepare sitagliptin, and a reaction formula is as follows: R1 and R2 are each independently selected from hydrogen, C1-C12 linear or branched alkyl, C3-C12 cycloalkyl, C2-C12 alkenyl, C2-C12 alkynyl and C7-C12 arylalkyl. The method has a high yield and a high ee % value, a mild reaction condition and a low production cost, and is simple to operate, convenient to purify, environmental friendly and suitable for industrial production.

公开(公告)号：US20180345260A1

公开(公告)日：2018-12-06

申请号：US15778376

申请日：2016-11-21

Applicant: MICROBIAL CHEMISTRY RESEARCH FOUNDATION

Inventor： Masakatsu SHIBASAKI ,  Naoya KUMAGAI ,  Akihito NONOYAMA ,  Kazuki HASHIMOTO ,  Akira SAITO

IPC: B01J31/22 ,  B01J37/04 ,  C07C201/12 ,  C07C205/16 ,  C07C205/54 ,  C07C237/04

CPC classification number: B01J31/22 ,  B01J37/04 ,  B01J2231/341 ,  B01J2531/004 ,  B01J2531/12 ,  B01J2531/38 ,  C07B61/00 ,  C07C201/12 ,  C07C205/16 ,  C07C205/32 ,  C07C205/54 ,  C07C237/04 ,  C07C237/22 ,  C07F7/003

Abstract: A catalyst including: neodymium; sodium; and a ligand, which is a compound expressed by Structural Formula (1) below, wherein the neodymium and the ligand form a complex at a molar ratio of 1:2 (neodymium:ligand):

公开(公告)号：US10052620B2

公开(公告)日：2018-08-21

申请号：US15102842

申请日：2014-12-04

Applicant: Chuanhua He ,  Benjamin Fonfe ,  Harald Jakob ,  Xiangyu Yang

Inventor： Chuanhua He ,  Benjamin Fonfe ,  Harald Jakob ,  Xiangyu Yang

IPC: C07C309/00 ,  B01J31/02 ,  B01J37/04 ,  B01J37/03 ,  C07C303/16 ,  C07C319/24 ,  B01J37/02

CPC classification number: B01J31/0239 ,  B01J23/22 ,  B01J23/8472 ,  B01J37/0236 ,  B01J37/031 ,  B01J37/04 ,  B01J2231/70 ,  B01J2531/004 ,  C07C303/16 ,  C07C319/24 ,  C07C309/04 ,  C07C321/14

Abstract: The present invention relates to a catalyst for oxidation reactions, particularly for oxidation of mercaptan dialkyldisulfides and/or dialklypolysulfides with oxygen to alkanesulfonic acids.

公开(公告)号：US10005709B2

公开(公告)日：2018-06-26

申请号：US15586494

申请日：2017-05-04

Applicant: SABIC GLOBAL TECHNOLOGIES B.V.

Inventor： Nathalie Gonzalez Vidal ,  Alexander van Goudswaard

IPC: C07C37/20 ,  B01J31/10 ,  B01J39/20 ,  C08J3/24 ,  B01J31/00

CPC classification number: C07C37/20 ,  B01J31/00 ,  B01J31/10 ,  B01J39/20 ,  B01J2231/34 ,  B01J2231/49 ,  B01J2531/004 ,  C08J3/24 ,  C08J2325/06 ,  C07C39/16

Abstract: In an embodiment, a method of producing a bisphenol comprises reacting a phenolic compound with a reactant comprising one or both of an aldehyde and a ketone in the presence of a catalyst system and methanol to produce the bisphenol; wherein the methanol is present in an amount of 250 to 5,000 ppm based on the total weight of the reactant; wherein the catalyst system comprises an ion-exchange resin comprising a plurality of sulfonic acid sites; and 5 to 35 mol % of an attached promoter molecule based on the total moles of the sulfonic acid sites in the catalyst system; and wherein the attached promoter molecule comprises at least two thiol groups per attached promoter molecule.

公开(公告)号：US09975866B2

公开(公告)日：2018-05-22

申请号：US15038416

申请日：2014-11-21

Applicant: DEPARTMENT OF BIOTECHNOLOGY, MINISTRY OF SCIENCE AND TECHNOLOGY, GOVERNMENT OF INDIA ,  INSTITUTE OF CHEMICAL TECHNOLOGY

Inventor： Arvind Mallinath Lali ,  Hitesh Suresh Pawar

IPC: C07D307/50 ,  B01J31/10 ,  C07D307/46 ,  B01J31/06 ,  B01J37/00 ,  B01J37/04

CPC classification number: C07D307/46 ,  B01J31/06 ,  B01J37/009 ,  B01J37/04 ,  B01J2231/4288 ,  B01J2531/004 ,  C07D307/50

Abstract: In accordance with the present subject matter, there is provided a process for preparing a furan derivative, the process comprising the steps of contacting a sugar with a monophasic organic solvent to obtain a reaction mixture; and subjecting the reaction mixture to a temperature in the range from 100° C. to 180° C., in presence of an acid catalyst, for a time period in the range of 0.5 min to 4.0 h to obtain at least 70% conversion of the sugar to a single furan derivative, wherein the acid catalyst is selected from the group consisting of homogenous acid catalyst, heterogenous solid acid catalyst, and combinations thereof. There is also provided a process for preparation of a heterogenous solid acid catalyst.

公开(公告)号：US20180133704A1

公开(公告)日：2018-05-17

申请号：US15102842

申请日：2014-12-04

Applicant: Chuanhua HE ,  Benjamin FONFE ,  Harald JAKOB ,  Xiangyu YANG

Inventor： Chuanhua HE ,  Benjamin FONFE ,  Harald JAKOB ,  Xiangyu YANG

IPC: B01J31/02 ,  B01J37/04 ,  B01J37/03 ,  B01J37/02 ,  C07C303/16 ,  C07C319/24

CPC classification number: B01J31/0239 ,  B01J23/22 ,  B01J23/8472 ,  B01J37/0236 ,  B01J37/031 ,  B01J37/04 ,  B01J2231/70 ,  B01J2531/004 ,  C07C303/16 ,  C07C319/24 ,  C07C309/04 ,  C07C321/14

Abstract: The present invention relates to a catalyst for oxidation reactions, particularly for oxidation of mercaptan dialkyldisulfides and/or dialklypolysulfides with oxygen to alkanesulfonic acids.