公开(公告)号：US20240409559A1

公开(公告)日：2024-12-12

申请号：US18698272

申请日：2022-10-04

Applicant: PFIZER INC.

Inventor： Fengjuan CAO ,  Martha Alicia ORNELAS

IPC: C07D519/00 ,  A61K31/444

Abstract: This disclosure relates to a crystalline form of 4-[(1R)-1-aminopropyl]-2-{6-[(5S)-5-methyl-6,7-dihydro-5H-pyrro-lo[2,1-c][1,2,4]triazol-3-yl]pyridin-2-yl}-6-[(2R)-2-methylpyrrolidin-1-yl]-2,3-dihydro-1H-pyrrolo[3,4-c]pyridin- 1-one (PF-07265028) free base and method of making thereof. The disclosure also relates to pharmaceutical compositions comprising this crystalline form, and to methods of using the crystalline form and such compositions for the treatment of abnormal cell growth, such as cancer, in a mammal.