公开(公告)号：US20240076287A1

公开(公告)日：2024-03-07

申请号：US18268959

申请日：2021-12-21

Applicant: PFIZER INC.

Inventor： Fengjuan CAO ,  Kevin Francis DEBOYACE ,  Michael HEBERLEIN

IPC: C07D403/12

CPC classification number: C07D403/12

Abstract: The invention relates to solid forms of (1R,3S)-3-[3-({[3-(methoxymethyl)-1-methyl-1H-pyrazol-5-yl]carbonyl}amino)-1H-pyrazol-5-yl]cyclopentyl propan-2-ylcarbamate, to pharmaceutical compositions comprising such solid forms, and to use of such solid forms and pharmaceutical compositions for the treatment of cancer.

公开(公告)号：US20240409559A1

公开(公告)日：2024-12-12

申请号：US18698272

申请日：2022-10-04

Applicant: PFIZER INC.

Inventor： Fengjuan CAO ,  Martha Alicia ORNELAS

IPC: C07D519/00 ,  A61K31/444

Abstract: This disclosure relates to a crystalline form of 4-[(1R)-1-aminopropyl]-2-{6-[(5S)-5-methyl-6,7-dihydro-5H-pyrro-lo[2,1-c][1,2,4]triazol-3-yl]pyridin-2-yl}-6-[(2R)-2-methylpyrrolidin-1-yl]-2,3-dihydro-1H-pyrrolo[3,4-c]pyridin- 1-one (PF-07265028) free base and method of making thereof. The disclosure also relates to pharmaceutical compositions comprising this crystalline form, and to methods of using the crystalline form and such compositions for the treatment of abnormal cell growth, such as cancer, in a mammal.