公开(公告)号：US20210395391A1

公开(公告)日：2021-12-23

申请号：US17283801

申请日：2019-10-09

Applicant: PFIZER INC.

Inventor： Tong Zhu ,  Steven Arkin ,  Matthew H. Cardinal ,  Chay Ngee Lim ,  Satyaprakash Nayak

IPC: C07K16/38 ,  A61K45/06 ,  A61P7/04

Abstract: Dosing regimens for the treatment of coagulation disorders using anti-TFPI antibodies are provided. The methods comprises administering to a subject in need there of an initial dose of about 50 mg to 500 mg of an anti-TFPI antibody or antigen-binding fragment thereof.

公开(公告)号：US20190231856A1

公开(公告)日：2019-08-01

申请号：US16157194

申请日：2018-10-11

Applicant: PFIZER INC.

Inventor： Steven Arkin ,  Marcus Carr ,  Joachim Fruebis ,  Sunita Hett ,  Reema Jasuja ,  Debra Pittman

IPC: A61K38/48

CPC classification number: A61K38/4846 ,  C12Y304/21006

Abstract: The disclosure provides compositions and methods for treating or preventing intracerebral hemorrhage (ICH) in a subject by administering a variant of FXa.

公开(公告)号：US20160375109A1

公开(公告)日：2016-12-29

申请号：US15112088

申请日：2015-01-15

Applicant: PFIZER INC.

Inventor： Steven Arkin ,  Marcus Carr ,  Joachim Fruebis ,  Sunita Hett ,  Reema Jasuja ,  Debra Pittman

IPC: A61K38/48

CPC classification number: A61K38/4846 ,  C12Y304/21006

Abstract: The disclosure provides compositions and methods for treating or preventing intracerebral hemorrhage (ICH) in a subject by administering a variant of FXa.

Abstract translation: 本公开提供了通过施用FXa的变体来治疗或预防受试者脑内出血（ICH）的组合物和方法。