公开(公告)号：US10588950B2

公开(公告)日：2020-03-17

申请号：US15873416

申请日：2018-01-17

Applicant: Pfizer Inc. ,  The Children's Hospital of Philadelphia

Inventor： Debra D. Pittman ,  Rodney M. Camire ,  Joachim Fruebis

IPC: A61K38/48 ,  A61K45/06 ,  C12N9/64 ,  A61K31/437 ,  A61K31/5377

Abstract: The disclosure provides compositions and methods for counteracting the effects of direct activated Factor X (FXa) inhibitors in a subject by administering a variant of FXa.

公开(公告)号：US20180344819A1

公开(公告)日：2018-12-06

申请号：US15873416

申请日：2018-01-17

Applicant: Pfizer Inc. ,  The Children's Hospital of Philadelphia

Inventor： Debra D. Pittman ,  Rodney M. Camire ,  Joachim Fruebis

IPC: A61K38/48 ,  C12N9/64 ,  A61K31/437 ,  A61K45/06 ,  A61K31/5377

CPC classification number: A61K38/4846 ,  A61K31/437 ,  A61K31/5377 ,  A61K45/06 ,  C12N9/6432 ,  C12Y304/21006 ,  A61K2300/00

Abstract: The disclosure provides compositions and methods for counteracting the effects of direct activated Factor X (FXa) inhibitors in a subject by administering a variant of FXa.

公开(公告)号：US20190231856A1

公开(公告)日：2019-08-01

申请号：US16157194

申请日：2018-10-11

Applicant: PFIZER INC.

Inventor： Steven Arkin ,  Marcus Carr ,  Joachim Fruebis ,  Sunita Hett ,  Reema Jasuja ,  Debra Pittman

IPC: A61K38/48

CPC classification number: A61K38/4846 ,  C12Y304/21006

Abstract: The disclosure provides compositions and methods for treating or preventing intracerebral hemorrhage (ICH) in a subject by administering a variant of FXa.

公开(公告)号：US20160375109A1

公开(公告)日：2016-12-29

申请号：US15112088

申请日：2015-01-15

Applicant: PFIZER INC.

Inventor： Steven Arkin ,  Marcus Carr ,  Joachim Fruebis ,  Sunita Hett ,  Reema Jasuja ,  Debra Pittman

IPC: A61K38/48

CPC classification number: A61K38/4846 ,  C12Y304/21006

Abstract: The disclosure provides compositions and methods for treating or preventing intracerebral hemorrhage (ICH) in a subject by administering a variant of FXa.

Abstract translation: 本公开提供了通过施用FXa的变体来治疗或预防受试者脑内出血（ICH）的组合物和方法。

公开(公告)号：US20150343034A1

公开(公告)日：2015-12-03

申请号：US14759520

申请日：2014-01-23

Applicant: PFIZER INC. ,  THE CHILDREN'S HOSPITAL OF PHILADELPHIA

Inventor： Debra D. Pittman ,  Rodney M. Camire ,  Joachim Fruebis

IPC: A61K38/48 ,  C12N9/64 ,  A61K45/06

CPC classification number: A61K38/4846 ,  A61K31/437 ,  A61K31/5377 ,  A61K45/06 ,  C12N9/6432 ,  C12Y304/21006 ,  A61K2300/00

Abstract: The disclosure provides compositions and methods for counteracting the effects of direct activated Factor X (FXa) inhibitors in a subject by administering a variant of FXa.

Abstract translation: 本公开提供了通过施用FXa的变体来抵消受试者中直接活化因子X（FXa）抑制剂的作用的组合物和方法。

公开(公告)号：US20210000930A1

公开(公告)日：2021-01-07

申请号：US16820687

申请日：2020-03-16

Applicant: Pfizer Inc. ,  The Children's Hospital of Philadelphia

Inventor： Debra D. Pittman ,  Rodney M. Camire ,  Joachim Fruebis

IPC: A61K38/48 ,  A61K45/06 ,  C12N9/64 ,  A61K31/437 ,  A61K31/5377

Abstract: The disclosure provides compositions and methods for counteracting the effects of direct activated Factor X (FXa) inhibitors in a subject by administering a variant of FXa.