公开(公告)号：US20230192839A1

公开(公告)日：2023-06-22

申请号：US16500970

申请日：2018-03-29

Applicant: PFIZER INC.

Inventor： Bijan Andre BOLDAJIPOUR ,  Javier Fernando CHAPARRO RIGGERS ,  Xiaodi DENG ,  Kevin Charles LINDQUIST ,  Spencer PARK ,  Edward Derrick PASCUA ,  Thomas John VAN BLARCOM

IPC: C07K16/28 ,  C07K16/00 ,  C12N15/63

CPC classification number: C07K16/28 ,  C07K16/005 ,  C12N15/63 ,  C07K2317/92 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2319/03

Abstract: Provided herein are antibodies with conditional affinity for an antigen. The affinity of an antibody with conditional affinity for an antigen may be altered by a small molecule agent. Antibodies with conditional affinity may be used therapeutically alone or in combination with other therapeutics to treat cancer and other diseases.