公开(公告)号：US20090070088A1

公开(公告)日：2009-03-12

申请号：US12060142

申请日：2008-03-31

申请人： Paul Brahznik ,  Kevin Hall ,  Dave Polidori ,  Scott Siler ,  Jeff Trimmer

发明人： Paul Brahznik ,  Kevin Hall ,  Dave Polidori ,  Scott Siler ,  Jeff Trimmer

IPC分类号： G06G7/60

CPC分类号： G16H50/50 ,  G16B5/00

摘要： The present invention relates generally to a mathematical and computer model of diabetes related disorders (e.g., human type 2 diabetes) within the framework of multiple macronutrient metabolism. The model includes a representation of complex physiological control mechanisms directing, for example, fat metabolism, protein metabolism and/or carbohydrate metabolism. In one embodiment, for example, the model can account for the interconversion between macronutrients, as well as their digestion, absorption, storage, mobilization, and adaptive utilization, as well as the endocrine control of these processes. In this embodiment, the model can simulate, for example, a heterogeneous group of diabetes related disorders, from insulin resistant to severe diabetic, and can predict the likely effects of therapeutic interventions.

摘要翻译： 本发明一般涉及在多种大量营养素代谢的框架内的糖尿病相关病症（例如人2型糖尿病）的数学和计算机模型。 该模型包括指导例如脂肪代谢，蛋白质代谢和/或碳水化合物代谢的复杂生理控制机制的表示。 在一个实施方案中，例如，该模型可以解释大量营养素之间的相互转化以及它们的消化，吸收，储存，动员和适应性利用以及这些过程的内分泌控制。 在该实施方案中，该模型可以模拟例如来自胰岛素抵抗重度糖尿病的异质性糖尿病相关疾病组，并且可以预测治疗干预的可能作用。