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    SEQUENCES CHARACTERISTIC OF HYPOXIA-REGULATED GENE TRANSCRIPTION
    1.
    发明申请
    SEQUENCES CHARACTERISTIC OF HYPOXIA-REGULATED GENE TRANSCRIPTION 审中-公开
    HYPOXIA调控基因转录的序列特征

    公开(公告)号：US20090264634A1

    公开(公告)日：2009-10-22

    申请号：US12269722

    申请日：2008-11-12

    申请人： Paz EINAT ,  Rami Skaliter ,  Elena Feinstein ,  Aviv Regev ,  Hagar Ralinski

    发明人： Paz EINAT ,  Rami Skaliter ,  Elena Feinstein ,  Aviv Regev ,  Hagar Ralinski

    IPC分类号： C07H21/04

    CPC分类号： C12Q1/6883 ,  A61K38/00 ,  A61K48/00 ,  C07K14/47 ,  C07K14/4702 ,  C07K14/4747 ,  C12N9/0004 ,  C12Q2600/158 ,  C12Y114/11004

    摘要： There are provided polynucleotides that are modulated by hypoxic conditions. The disclosure includes such genes and proteins as well as analogs, salts and functional derivatives of such proteins, and DNA encoding such analogs, and methods of use. Methods for treating the effects of stroke, hypoxia and/or ischemia by regulating such genes or proteins are also disclosed. The presence of hypoxia or a hypoxia-associated pathology may be diagnosed by screening for the presence of at least one polynucleotide having the nucleic acid sequence according to the present invention. Methods of regulating hypoxia associated pathologies are also provided.

    摘要翻译： 提供了由缺氧条件调节的多核苷酸。 本公开包括此类基因和蛋白质以及此类蛋白质的类似物，盐和功能性衍生物，以及编码此类类似物的DNA及其使用方法。 还公开了通过调节这些基因或蛋白质治疗中风，缺氧和/或缺血的作用的方法。 可以通过筛选至少一种具有本发明的核酸序列的多核苷酸的存在来诊断缺氧或缺氧相关病理的存在。 还提供了调节缺氧相关病变的方法。

    GENES ASSOCIATED WITH MECHANICAL STRESS, EXPRESSION PRODUCTS THEREFROM, AND USES THEREOF
    2.
    发明申请
    GENES ASSOCIATED WITH MECHANICAL STRESS, EXPRESSION PRODUCTS THEREFROM, AND USES THEREOF 审中-公开
    与机械应力相关的基因，其表达产物及其用途

    公开(公告)号：US20090258021A1

    公开(公告)日：2009-10-15

    申请号：US11841827

    申请日：2007-08-20

    申请人： Paz EINAT ,  Orit Segev ,  Rami Skaliter ,  Elena Feinstein ,  Alexander Faerman ,  Aviva Samach

    发明人： Paz EINAT ,  Orit Segev ,  Rami Skaliter ,  Elena Feinstein ,  Alexander Faerman ,  Aviva Samach

    IPC分类号： A61K39/395 ,  C07K14/00 ,  C07K16/18 ,  A61P35/00

    CPC分类号： C07H21/04 ,  C07K14/47 ,  C07K16/18

    摘要： The disclosure relates to human and mechanical stress induced genes, in particular gene 608, and functional equivalents, probes therefor, tests to identify such genes, polypeptide expression products of such genes, antibodies to the polypeptides, uses for such genes, expression products and antibodies, e.g., in diagnosis (for instance risk determination), treatment, prevention, or control, of osteoporosis or fractures; and to diagnostic, treatment, prevention, or control methods or processes, as well as compositions therefor and methods or processes for making and using such compositions, and receptors therefor and methods or processes for obtaining and using such receptors.

    摘要翻译： 本公开涉及人和机械应激诱导的基因，特别是基因608和功能等同物，其探针，鉴定这些基因的测试，这些基因的多肽表达产物，对多肽的抗体，用于这些基因，表达产物和抗体 ，例如骨质疏松症或骨折的诊断（例如风险确定），治疗，预防或控制; 以及诊断，治疗，预防或控制方法或过程，以及其组合物以及用于制备和使用这些组合物及其受体的方法或方法以及用于获得和使用这些受体的方法或方法。