公开(公告)号：US12116368B2

公开(公告)日：2024-10-15

申请号：US17286018

申请日：2019-10-21

Applicant: Pfizer Inc.

Inventor： Brian Matthew Samas ,  Yong Tao ,  Douglas James Critcher ,  David Sydney Bernard Daniels ,  Kevin Paul Girard ,  Gregory Scott Goeken ,  Peter Robert Rose

IPC: C07D487/04

CPC classification number: C07D487/04 ,  C07B2200/13

Abstract: The present invention discloses a novel p-toluenesulfonic acid salt and a crystalline polymorphic Form 1 of said salt of 1-((2S,5R)-5-((7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)-2-methylpiperidin-1-yl)prop-2-en-1-one, pharmaceutical composition containing the same, as well as preparations and uses thereof. The present invention also discloses a novel phosphoric acid salt of 1-((2S,5R)-5-((7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)-2-methylpiperidin-1-yl)prop-2-en-1-one, pharma-ceutical composition containing the same, as well as preparations and uses thereof.

公开(公告)号：US20230219963A1

公开(公告)日：2023-07-13

申请号：US17997091

申请日：2021-05-25

Applicant: Pfizer Inc.

Inventor： Martin Eugene Dowty ,  Bimal Kumar Malhotra ,  Ivan Jordan Samardjiev ,  Brian Matthew Samas ,  Joseph Walter Strohbach

IPC: C07D487/04

CPC classification number: C07D487/04

Abstract: Described herein are pyrrolo{2,3-d}pyrimidine derivatives, their use as Janus Kinase (JAK) inhibitors, and pharmaceutical compositions containing them.

公开(公告)号：US20250066337A1

公开(公告)日：2025-02-27

申请号：US18684225

申请日：2022-08-23

Applicant: Pfizer Inc.

Inventor： Kevin Francis DeBoyace ,  Brian Matthew Samas ,  Heather Lynn Frericks Schmidt

IPC: C07D405/14 ,  A61K31/506 ,  A61K45/06

Abstract: Solid forms of (S)-2-(5-((3-ethoxypyridin-2-yl)oxy)pyridin-3-yl)-N-(tetrahydrofuran-3-yl)pyrimidine-5-carboxamide, including crystalline forms and an amorphous form, in addition to pharmaceutical compositions, processes for preparing, and their use to treat diseases, conditions and disorders modulated by the activity of the diacylglycerol acyltransferase 2 (DGAT2) in a mammal such as a human are described herein.