公开(公告)号：US09770441B1

公开(公告)日：2017-09-26

申请号：US15509343

申请日：2015-08-31

Applicant: Pfizer Inc.

Inventor： Kevin Paul Girard ,  Andrew J. Jensen ,  Kris Nicole Jones

IPC: C07D263/57 ,  A61K31/423

CPC classification number: A61K31/423 ,  C07B2200/13 ,  C07D263/57

Abstract: The present invention relates to solid forms of 6-carboxy-2-(3,5-dichlorophenyl)-benzoxazole and to methods for their preparation. The invention is also directed to pharmaceutical compositions containing at least one solid form and to the therapeutic or prophylactic use of such solid forms and compositions.

公开(公告)号：US12116368B2

公开(公告)日：2024-10-15

申请号：US17286018

申请日：2019-10-21

Applicant: Pfizer Inc.

Inventor： Brian Matthew Samas ,  Yong Tao ,  Douglas James Critcher ,  David Sydney Bernard Daniels ,  Kevin Paul Girard ,  Gregory Scott Goeken ,  Peter Robert Rose

IPC: C07D487/04

CPC classification number: C07D487/04 ,  C07B2200/13

Abstract: The present invention discloses a novel p-toluenesulfonic acid salt and a crystalline polymorphic Form 1 of said salt of 1-((2S,5R)-5-((7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)-2-methylpiperidin-1-yl)prop-2-en-1-one, pharmaceutical composition containing the same, as well as preparations and uses thereof. The present invention also discloses a novel phosphoric acid salt of 1-((2S,5R)-5-((7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)-2-methylpiperidin-1-yl)prop-2-en-1-one, pharma-ceutical composition containing the same, as well as preparations and uses thereof.

公开(公告)号：US20210387989A1

公开(公告)日：2021-12-16

申请号：US17286018

申请日：2019-10-21

Applicant: Pfizer Inc.

Inventor： Brian Matthew SAMAS ,  Yong TAO ,  Douglas James Critcher ,  David Sydney Bernard Daniels ,  Kevin Paul Girard ,  Gregory Scott Goeken ,  Peter Robert Rose

IPC: C07D487/04

Abstract: The present invention discloses a novel p-toluenesulfonic acid salt and a crystalline polymorphic Form 1 of said salt of 1-((2S,5R)-5-((7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)-2-methylpiperidin-1-yl)prop-2-en-1-one, pharmaceutical composition containing the same, as well as preparations and uses thereof. The present invention also discloses a novel phosphoric acid salt of 1-((2S,5R)-5-((7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)-2-methylpiperidin-1-yl)prop-2-en-1-one, pharmaceutical composition containing the same, as well as preparations and uses thereof.