公开(公告)号：US20220401544A1

公开(公告)日：2022-12-22

申请号：US17764153

申请日：2020-09-24

Applicant: Pfizer Inc.

Inventor： Annaliesa Sybil Anderson ,  John Lance Perez ,  Kathrin Ute Jansen ,  Paul Liberator ,  Cuiwen Tan ,  Thomas Richard Jones ,  Johannes Frederik Beeslaar ,  Judith Absalon ,  Jason Douglas Maguire ,  Shannon Lea Harris

IPC: A61K39/095 ,  A61P31/04 ,  A61K47/02

Abstract: NEW MATERIAL: Recombinant plasmid pTPGIF2 having a size of 4,660 base pairs and a structure obtained by inserting a DNA having a size of 52 base pairs and containing a sequence coding somatostatin into a BamHI incision site of a plasmid vector pTP70-1 capable or fusing a heteropeptide to a carboxy-terminal of a dihydrofolic acid reductase gene of E. coli. USE: Producton of fused protein containing somatostatin.
PREPARATION: A somatostatin gene is integrated into a plasmid vector pTP70-1. pTPGIF2 is kept in stable state when introduced into E. coli. C600 strain. The E. coli. C600 train containing pTPGIF2 is deposited in Fermentation Research institute as FERM BP-1577.