公开(公告)号：US20190092750A1

公开(公告)日：2019-03-28

申请号：US16206166

申请日：2018-11-30

Applicant: PFIZER INC.

Inventor： KATHERINE LIN LEE ,  CHRISTOPHE PHILIPPE ALLAIS ,  CHRISTOPH MARTIN DEHNHARDT ,  LORI KRIM GAVRIN ,  SEUNGIL HAN ,  DAVID HEPWORTH ,  ARTHUR LEE ,  FRANK ELDRIDGE LOVERING ,  JOHN PAUL MATHIAS ,  DAFYDD RHYS OWEN ,  NIKOLAOS PAPAIOANNOU ,  EDDINE SAIAH ,  JOSEPH WALTER STROHBACH ,  JOHN DAVID TRZUPEK ,  STEPHEN WAYNE WRIGHT ,  CHRISTOPH WOLFGANG ZAPF

IPC: C07D401/12 ,  C07D413/04 ,  A61K31/4375 ,  A61K31/4709 ,  A61K31/4725 ,  A61K31/4745 ,  A61K45/06 ,  C07D401/14 ,  C07D207/273 ,  C07D491/18 ,  C07D471/04 ,  C07D413/14 ,  A61K31/4015

Abstract: Compounds, tautomers and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula 1a, as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

公开(公告)号：US20180244646A1

公开(公告)日：2018-08-30

申请号：US15754650

申请日：2016-08-16

Applicant: PFIZER INC.

Inventor： KATHERINE LIN LEE ,  CHRISTOPHE PHILIPPE ALLAIS ,  CHRISTOPH MARTIN DEHNHARDT ,  LORI KRIM GAVRIN ,  SEUNGIL HAN ,  DAVID HEPWORTH ,  ARTHUR LEE ,  FRANK ELDRIDGE LOVERING ,  JOHN PAUL MATHIAS ,  DAFYDD RHYS OWEN ,  NIKOLAOS PAPAIOANNOU ,  EDDINE SAIAH ,  JOSEPH WALTER STROHBACH ,  JOHN DAVID TRZUPEK ,  STEPHEN WAYNE WRIGHT ,  CHRISTOPH WOLFGANG ZAPF

IPC: C07D401/12 ,  A61K31/4709 ,  C07D413/14 ,  A61K31/4725 ,  A61K45/06 ,  C07D401/14 ,  C07D413/04 ,  C07D207/273 ,  A61K31/4015 ,  C07D491/18 ,  A61K31/4745 ,  C07D471/04 ,  A61K31/4375

CPC classification number: C07D401/12 ,  A61K31/4015 ,  A61K31/4375 ,  A61K31/4709 ,  A61K31/4725 ,  A61K31/4745 ,  A61K45/06 ,  C07D207/273 ,  C07D401/14 ,  C07D413/04 ,  C07D413/14 ,  C07D471/04 ,  C07D491/18

Abstract: Compounds, tautomers and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula Ia, as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

公开(公告)号：US20230339960A1

公开(公告)日：2023-10-26

申请号：US18342977

申请日：2023-06-28

Applicant: Pfizer Inc.

Inventor： JOHN DAVID TRZUPEK ,  KATHERINE LIN LEE ,  MARK EDWARD BUNNAGE ,  SEUNGIL HAN ,  DAVID HEPWORTH ,  FRANK ELDRIDGE LOVERING ,  JOHN PAUL MATHIAS ,  NIKOLAOS PAPAIOANNOU ,  BETSY SUSAN PIERCE ,  JOSEPH WALTER STROHBACH ,  STEPHEN WAYNE WRIGHT ,  CHRISTOPH WOLFGANG ZAPF ,  LORI KRIM GAVRIN ,  ARTHUR LEE ,  DAVID RANDOLPH ANDERSON ,  KEVIN JOSEPH CURRAN ,  CHRISTOPH MARTIN DEHNHARDT ,  EDDINE SAIAH ,  JOEL ADAM GOLDBERG ,  XIAOLUN WANG ,  HORNG-CHIH HUANG ,  RICHARD VARGAS ,  MICHAEL DENNIS LOWE ,  AKSHAY PATNY

IPC: C07D491/056 ,  C07F7/18 ,  A61K31/4015 ,  A61K31/47 ,  A61K31/4709 ,  A61K31/4725 ,  A61K31/517 ,  A61K31/5377 ,  A61K31/541 ,  A61K45/06 ,  C07C69/94 ,  C07D207/08 ,  C07D207/26 ,  C07D207/267 ,  C07D207/273 ,  C07D209/52 ,  C07D215/48 ,  C07D217/02 ,  C07D217/22 ,  C07D217/24 ,  C07D239/86 ,  C07D239/88 ,  C07D263/24 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D407/14 ,  C07D413/12 ,  C07D417/12 ,  C07D487/04 ,  C07D498/04 ,  A61K31/40

CPC classification number: C07D491/056 ,  C07F7/1804 ,  A61K31/4015 ,  A61K31/47 ,  A61K31/4709 ,  A61K31/4725 ,  A61K31/517 ,  A61K31/5377 ,  A61K31/541 ,  A61K45/06 ,  C07C69/94 ,  C07D207/08 ,  C07D207/26 ,  C07D207/267 ,  C07D207/273 ,  C07D209/52 ,  C07D215/48 ,  C07D217/02 ,  C07D217/22 ,  C07D217/24 ,  C07D239/86 ,  C07D239/88 ,  C07D263/24 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D407/14 ,  C07D413/12 ,  C07D417/12 ,  C07D487/04 ,  C07D498/04 ,  A61K31/40

Abstract: Compounds, tautomers and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula Ia,




as defined in the specification. In an embodiment, a pharmaceutical composition can be in a liquid dosage form and can comprise a therapeutically effective amount of the compound or a pharmaceutically acceptable salt thereof as an adjuvant and a therapeutic agent. In another embodiment, a method of adjuvant treating a disorder or condition can comprising administering the pharmaceutical composition to a patient.

公开(公告)号：US20160303125A1

公开(公告)日：2016-10-20

申请号：US15193440

申请日：2016-06-27

Applicant: PFIZER INC.

Inventor： SHAWN CABRAL ,  KENTARO FUTATSUGI ,  DAVID HEPWORTH ,  KIM HUARD ,  DANIEL WEI-SHUNG KUNG ,  SUVI TUULA MARJUKKA ORR ,  KUN SONG

IPC: A61K31/506 ,  A61K45/06

CPC classification number: A61K31/506 ,  A61K31/4545 ,  A61K31/5377 ,  A61K31/606 ,  A61K45/06 ,  C07D401/04 ,  C07D401/14 ,  C07D413/14 ,  C07D487/02 ,  C07D487/04 ,  C07D491/08

Abstract: Compounds of Formula I that inhibit the activity of the diacylglycerol acyltransferase 2 (DGAT2) and their uses in the treatment of diseases linked thereto in animals are described herein.

公开(公告)号：US20150259323A1

公开(公告)日：2015-09-17

申请号：US14643210

申请日：2015-03-10

Applicant: PFIZER INC.

Inventor： SHAWN CABRAL ,  KENTARO FUTATSUGI ,  DAVID HEPWORTH ,  KIM HUARD ,  DANIEL WEI-SHUNG KUNG ,  SUVI TUULA MARJUKKA ORR ,  KUN SONG

IPC: C07D401/04 ,  A61K31/506 ,  A61K31/4545 ,  C07D491/08 ,  A61K31/606 ,  C07D413/14 ,  A61K31/5377 ,  C07D487/02 ,  A61K45/06 ,  C07D401/14

CPC classification number: A61K31/506 ,  A61K31/4545 ,  A61K31/5377 ,  A61K31/606 ,  A61K45/06 ,  C07D401/04 ,  C07D401/14 ,  C07D413/14 ,  C07D487/02 ,  C07D487/04 ,  C07D491/08

Abstract: Compounds of Formula I that inhibit the activity of the diacylglycerol acyltransferase 2 (DGAT2) and their uses in the treatment of diseases linked thereto in animals are described herein.

Abstract translation: 本文描述了抑制二酰基甘油酰基转移酶2（DGAT2）的活性的式I化合物及其在治疗与动物相关疾病中的用途。