公开(公告)号：US20240117030A1

公开(公告)日：2024-04-11

申请号：US18175796

申请日：2023-02-28

Applicant: Pfizer Inc.

Inventor： Rita Diane AGOSTINELLI ,  James Reasoner APGAR ,  Eric Matthew BENNETT ,  Laird BLOOM ,  Ting CHEN ,  Aaron Michael D'ANTONA ,  Arnab DE ,  Fang JIN ,  Marion Teresa KASAIAN ,  Matthew Allister LAMBERT ,  Kimberly Ann MARQUETTE ,  Virginie MCMANUS ,  Jessica Haewon MIN DEBARTOLO ,  Nicole Melissa PICHE-NICHOLAS ,  Richard Thomas SHELDON ,  Lioudmila TCHISTIAKOVA ,  Alexander Michael Shuford BARRON ,  Richard Lee GIESECK, III ,  Xiaotian ZHONG

IPC: C07K16/24 ,  A61K45/06 ,  A61P35/00

CPC classification number: C07K16/247 ,  A61K45/06 ,  A61P35/00 ,  A61K2039/505

Abstract: The present invention relates to antibodies that specifically bind to one or more of IL-4, IL-13, IL-33, TSLP, and p40. The present invention further relates to antibodies that bind to one of IL-4, IL-13, IL-33, or TSLP. The invention further relates to multispecific antibodies that specifically bind to IL-4 and IL-13, and at least one other target. The present invention relates to multispecific antibodies that bind IL-4, IL-13, and one of IL-33, TSLP, or p40. The present invention also pertains to related molecules, e.g. nucleic acids which encode such antibodies or multispecific antibodies, compositions, and related methods, e.g., methods for producing and purifying such antibodies and multispecific antibodies, and their use in diagnostics and therapeutics.

公开(公告)号：US20200308272A1

公开(公告)日：2020-10-01

申请号：US16729421

申请日：2019-12-29

Applicant: Pfizer Inc.

Inventor： Laird BLOOM ,  Karl Henry NOCKA ,  James Reasoner APGAR ,  Matthew Allister LAMBERT ,  Mark A. FARMER

IPC: C07K16/24 ,  A61K39/395

Abstract: The invention provides antibodies, and antigen-binding fragments thereof, that specifically bind to IL-33, as well as uses, and associated methods thereof.

公开(公告)号：US20180037644A1

公开(公告)日：2018-02-08

申请号：US15495172

申请日：2017-04-24

Applicant: Pfizer Inc.

Inventor： Laird BLOOM ,  Karl Henry NOCKA ,  James Reasoner APGAR ,  Matthew Allister LAMBERT ,  Mark A. FARMER

IPC: C07K16/24 ,  A61K39/395

Abstract: The invention provides antibodies, and antigen-binding fragments thereof, that specifically bind to IL-33, as well as uses, and associated methods thereof.

公开(公告)号：US20240360214A1

公开(公告)日：2024-10-31

申请号：US18639118

申请日：2024-04-18

Applicant: PFIZER INC.

Inventor： James Reasoner APGAR ,  Wei CAO ,  Timothy HEMESATH ,  Christina Lynn O'HALLORAN ,  Lan WU ,  Ming ZHU

IPC: C07K16/28 ,  A61K39/00 ,  A61P35/00

CPC classification number: C07K16/2803 ,  A61P35/00 ,  C07K16/2818 ,  A61K2039/505 ,  A61K2039/507 ,  C07K2317/31 ,  C07K2317/76 ,  C07K2317/92

Abstract: The invention is directed to Anti-LILRB1 and anti-LILRB2 bispecific antibodies, anti-LILRB1 antibodies, and anti-LILRB2 antibodies, their uses and pharmaceutical compositions thereof.

公开(公告)号：US20240059799A1

公开(公告)日：2024-02-22

申请号：US18314339

申请日：2023-05-09

Applicant: Pfizer Inc. ,  Bristol-Myers Squibb Company

Inventor： James Reasoner APGAR ,  Laird BLOOM ,  Fang JIN ,  Fridrik KARLSSON ,  Kimberly Ann MARQUETTE ,  Jessica Haewon MIN DEBARTOLO ,  Nicole Melissa PICHE-NICHOLAS ,  Lioudmila TCHISTIAKOVA

IPC: C07K16/46 ,  A61P37/02 ,  C12N15/63

CPC classification number: C07K16/468 ,  A61P37/02 ,  C12N15/63 ,  C07K2317/14 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/92

Abstract: The present invention discloses an isolated antibody that specifically binds to TL1A, comprising a heavy chain variable region (TL1A-VH) and a light chain variable region (TL1A-VL), comprising the CDR-H1, CDR-H2, and CDR-H3 sequences of a TL1A-VH sequence selected from the group consisting of SEQ ID NO: 42, SEQ ID NO: 44, SEQ ID NO: 47, SEQ ID NO: 49, SEQ ID NO: 52, SEQ ID NO: 54, SEQ ID NO: 57, SEQ ID NO: 70, SEQ ID NO: 72, SEQ ID NO: 78, SEQ ID NO: 80, SEQ ID NO: 89, SEQ ID NO: 93, SEQ ID NO: 95, SEQ ID NO: 97, SEQ ID NO: 99, SEQ ID NO: 101, SEQ ID NO: 103, SEQ ID NO: 105, SEQ ID NO: 110, SEQ ID NO: 120; and the CDR-L1, CDR-L2, and CDR-L3 sequences of SEQ ID NO: 18.

公开(公告)号：US20240010696A1

公开(公告)日：2024-01-11

申请号：US18335259

申请日：2023-06-15

Applicant: Pfizer Inc.

Inventor： James Reasoner APGAR ,  Javier Fernando CHAPARRO RIGGERS ,  Ling Hon Matthew CHU ,  Tzu-Hsuan HUANG ,  Kritika MOHAN ,  Lidia MOSYAK ,  Edward Derrick PASCUA ,  James Travis PATTERSON ,  Gabriel Roy STARBECK-MILLER ,  Dirk Michael ZAJONC

IPC: C07K14/54 ,  C07K16/28 ,  A61P35/00 ,  C12N15/63

CPC classification number: C07K14/5434 ,  C07K16/2818 ,  A61P35/00 ,  C12N15/63 ,  C07K2317/565

Abstract: IL-12 variants are provided. Also provided are antibodies that specifically bind to PD1. Also provided are fusion proteins of IL-12 variants and anti-PD1 antibodies. Also provided are uses of these IL-12 variants, anti-PD1 antibodies, fusion proteins, and related compositions and methods.

公开(公告)号：US20230365701A1

公开(公告)日：2023-11-16

申请号：US18315054

申请日：2023-05-10

Applicant: Pfizer Inc.

Inventor： James Reasoner APGAR ,  Bas Joannes Gertrudis BAATEN ,  Aruna BITRA ,  Javier Fernando CHAPARRO RIGGERS ,  Giuseppe DI CARO ,  Pawel Kamil DOMINIK ,  Zachary John MABEN ,  Lidia MOSYAK ,  Andrew Ross NAGER ,  Cecilia Marianne ODERUP ,  Edward Derrick PASCUA ,  Shahram SALEK-ARDAKANI ,  Dirk Michael ZAJONC

IPC: C07K16/28 ,  A61P35/00

CPC classification number: C07K16/2878 ,  A61P35/00 ,  C07K2317/35 ,  C07K2317/71 ,  C07K2317/92 ,  A61K2039/505

Abstract: Antibodies that specifically bind to LTBR are provided. Also provided are uses of these antibodies, and related compositions and methods.