公开(公告)号：US20240010696A1

公开(公告)日：2024-01-11

申请号：US18335259

申请日：2023-06-15

Applicant: Pfizer Inc.

Inventor： James Reasoner APGAR ,  Javier Fernando CHAPARRO RIGGERS ,  Ling Hon Matthew CHU ,  Tzu-Hsuan HUANG ,  Kritika MOHAN ,  Lidia MOSYAK ,  Edward Derrick PASCUA ,  James Travis PATTERSON ,  Gabriel Roy STARBECK-MILLER ,  Dirk Michael ZAJONC

IPC: C07K14/54 ,  C07K16/28 ,  A61P35/00 ,  C12N15/63

CPC classification number: C07K14/5434 ,  C07K16/2818 ,  A61P35/00 ,  C12N15/63 ,  C07K2317/565

Abstract: IL-12 variants are provided. Also provided are antibodies that specifically bind to PD1. Also provided are fusion proteins of IL-12 variants and anti-PD1 antibodies. Also provided are uses of these IL-12 variants, anti-PD1 antibodies, fusion proteins, and related compositions and methods.