公开(公告)号：US12116368B2

公开(公告)日：2024-10-15

申请号：US17286018

申请日：2019-10-21

Applicant: Pfizer Inc.

Inventor： Brian Matthew Samas ,  Yong Tao ,  Douglas James Critcher ,  David Sydney Bernard Daniels ,  Kevin Paul Girard ,  Gregory Scott Goeken ,  Peter Robert Rose

IPC: C07D487/04

CPC classification number: C07D487/04 ,  C07B2200/13

Abstract: The present invention discloses a novel p-toluenesulfonic acid salt and a crystalline polymorphic Form 1 of said salt of 1-((2S,5R)-5-((7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)-2-methylpiperidin-1-yl)prop-2-en-1-one, pharmaceutical composition containing the same, as well as preparations and uses thereof. The present invention also discloses a novel phosphoric acid salt of 1-((2S,5R)-5-((7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)-2-methylpiperidin-1-yl)prop-2-en-1-one, pharma-ceutical composition containing the same, as well as preparations and uses thereof.