公开(公告)号：US20150259392A1

公开(公告)日：2015-09-17

申请号：US14433047

申请日：2013-03-05

Applicant: RAMOT AT TEL-AVIV UNIVERSITY LTD.

Inventor： Daniel Offen ,  Israel Aharony

IPC: C07K14/47

CPC classification number: C07K14/47 ,  A61K38/00 ,  C07K14/4703 ,  C07K14/8139 ,  C07K2319/10

Abstract: An isolated peptide comprising a Huntingtin (Htt) amino acid sequence being no longer than 15 amino acids, wherein said Htt amino acid sequence comprises the sequence X1X2X3X4 X5, wherein X1 is a hydrophobic amino acid or threonine, X2 is a hydrophobic amino acid, X3 is a hydrophobic amino acid, X4 is an acidic amino acid and X5 is selected from the group consisting of glycine, serine and alanine, the peptide capable of specifically inhibiting the activity of caspase 6.

Abstract translation: 一种分离的肽，其包含不超过15个氨基酸的亨廷丁（Htt）氨基酸序列，其中所述Htt氨基酸序列包含序列X1X2X3X4X5，其中X1是疏水性氨基酸或苏氨酸，X2是疏水性氨基酸，X3 是疏水性氨基酸，X4是酸性氨基酸，X5选自甘氨酸，丝氨酸和丙氨酸，能够特异性抑制胱天蛋白酶6活性的肽。

公开(公告)号：US10040836B2

公开(公告)日：2018-08-07

申请号：US15404378

申请日：2017-01-12

Applicant: Ramot at Tel-Aviv University Ltd.

Inventor： Daniel Offen ,  Israel Aharony

IPC: C07K14/47 ,  C07K14/81 ,  A61K38/00

Abstract: An isolated peptide comprising a Huntingtin (Htt) amino acid sequence being no longer than 15 amino acids, wherein said Htt amino acid sequence comprises the sequence X1X2X3X4 X5, wherein X1 is a hydrophobic amino acid or threonine, X2 is a hydrophobic amino acid, X3 is a hydrophobic amino acid, X4 is an acidic amino acid and X5 is selected from the group consisting of glycine, serine and alanine, the peptide capable of specifically inhibiting the activity of caspase 6.

公开(公告)号：US09598478B2

公开(公告)日：2017-03-21

申请号：US14433047

申请日：2013-03-05

Applicant: Ramot at Tel-Aviv University Ltd.

Inventor： Daniel Offen ,  Israel Aharony

IPC: C07K14/47 ,  A61K38/00

CPC classification number: C07K14/47 ,  A61K38/00 ,  C07K14/4703 ,  C07K14/8139 ,  C07K2319/10

Abstract: An isolated peptide comprising a Huntingtin (Htt) amino acid sequence being no longer than 15 amino acids, wherein said Htt amino acid sequence comprises the sequence X1X2X3X4 X5, wherein X1 is a hydrophobic amino acid or threonine, X2 is a hydrophobic amino acid, X3 is a hydrophobic amino acid, X4 is an acidic amino acid and X5 is selected from the group consisting of glycine, serine and alanine, the peptide capable of specifically inhibiting the activity of caspase 6.