公开(公告)号：US20240398839A1

公开(公告)日：2024-12-05

申请号：US18694614

申请日：2022-09-22

Applicant: RAMOT AT TEL-AVIV UNIVERSITY LTD.

Inventor： Daniel OFFEN ,  Nataly YOM-TOV

IPC: A61K31/00 ,  A61K47/54

Abstract: Provided is a cannabinoid-phospholipid conjugate where the cannabinoid is covalently linked, via a cleavable linker, to a polar head group of the phospholipid. Also provided is a method of obtaining the conjugate, the method comprising (a) reacting the phospholipid (PL) dissolved in an organic solvent with maleic anhydride (MA) to obtain PL-MA intermediate; and (b) reacting said PL-MA intermediate with the cannabinoid in the presence of a carboxyl activating agent and an esterification agent to obtain a reaction mixture comprising said conjugate. Uses of the conjugate are also disclosed.

公开(公告)号：US20240245720A1

公开(公告)日：2024-07-25

申请号：US18564356

申请日：2022-05-25

Applicant: RAMOT AT TEL-AVIV UNIVERSITY LTD.

Inventor： Daniel OFFEN ,  Nataly YOM-TOV

IPC: A61K31/785 ,  A61K9/50 ,  A61K9/51 ,  B82Y5/00

CPC classification number: A61K31/785 ,  A61K9/5068 ,  A61K9/5146 ,  A61K9/5161 ,  B82Y5/00

Abstract: The present disclosure provides a composition comprising an extracellular vesicle (EV) associated with an active agent and a polymer, wherein said polymer carries at least one positively charged moiety or has at least one positive pole and said active agent carries, independently, at least one negatively charged moiety or has at least one negative pole; and wherein said polymer and said active agent are present at a positive to negative charge or pole ratio of at least 2. A preferred example relates to a composition wherein the polymer is polyethyleneimine, the agent is a nucleic acid and the EV is an exosome. The present disclosure also provides methods for obtaining the composition and uses of the composition.