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    PROCESS FOR THE MANUFACTURE OF AN AMINO ESTER
    1.
    发明申请
    PROCESS FOR THE MANUFACTURE OF AN AMINO ESTER 审中-公开
    制备氨基酸的方法

    公开(公告)号：US20160289167A1

    公开(公告)日：2016-10-06

    申请号：US15037446

    申请日：2014-11-18

    Applicant: RHODIA OPERATIONS

    Inventor： Philippe MARION ,  Didier MORVAN

    IPC: C07C227/04 ,  C08G69/44 ,  C07C253/30

    CPC classification number: C07C227/04 ,  C07C253/30 ,  C08G69/44 ,  C07C255/23 ,  C07C229/08

    Abstract: Process for the manufacture of an amino ester of formula (I) R1—O—C(O)—(CH2)n—NH2 (I) in which n is an integer from 10 to 15 from an unsaturated ester responding to formula (II) R1—O—C(O)—(CH2)m—CH═CH—R2 (II) in which R1 is either H or a saturated alkyl group containing from 1 to 5 carbon atoms; R2 is either H or an alkyl group containing from 1 to 10 carbon atoms, either saturated or containing 1 or 2 unsaturations and bearing optionally a hydroxyl, a carboxylic or an ester group, and m is equal to 7, 8, 9, 10 or 11; said process comprising: submitting the unsaturated ester of formula (II) to a catalytic cross-metathesis reaction with a pentenenitrile chosen among 2-pentenenitrile or 3-pentenenitrile in order to obtain a ester-nitrile responding to formula (III) R1—O—C(O)—(CH2)m—CH═CH—(CH2)p—CN (III) in which m is equal to 7, 8, 9, 10 or 11 and p is equal to 0 or 1, and submitting the obtained ester-nitrile of formula (III) to an hydrogenation in order to obtain the amino ester of formula (I).

    Abstract translation: 制备式（I）的氨基酯的方法R1-O-C（O） - （CH2）n-NH2（Ⅰ）其中n为10-15的整数， ）R 1为H或含有1至5个碳原子的饱和烷基的R 1 -O-C（O） - （CH 2）m -CH = CH-R 2（II） R 2是H或含有1至10个碳原子的烷基，其为饱和的或含有1或2个不饱和基团，并且任选具有羟基，羧基或酯基，m等于7,8,9,10或 11; 所述方法包括：将式（II）的不饱和酯与选自2-戊烯腈或3-戊烯腈的戊烯腈进行催化交叉复分解反应，以获得响应式（III）的酯腈R 1 -O- C（O） - （CH2）m-CH = CH-（CH2）p-CN（III），其中m等于7,8,9,10或11，p等于0或1， 得到式（III）的酯腈进行氢化，得到式（I）的氨基酯。

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