公开(公告)号：US20240009319A1

公开(公告)日：2024-01-11

申请号：US18347280

申请日：2023-07-05

Applicant: RINAT NEUROSCIENCE CORP.

Inventor： Santiago Esteban FARIAS ,  Meritxell GALINDO CASAS ,  Pavel STROP

IPC: A61K47/68

CPC classification number: A61K47/6803 ,  A61K47/68 ,  A61K47/6817 ,  A61K47/6809 ,  A61K47/6805

Abstract: The present invention provides engineered polypeptide conjugates (e.g., antibody-drug-conjugates) comprising specific acyl donor glutamine-containing tags and amine donor agents. The invention also provides methods of making such engineered polypeptide conjugates using transglutaminase and methods of using thereof.

公开(公告)号：US20160193356A1

公开(公告)日：2016-07-07

申请号：US14908492

申请日：2014-07-30

Applicant: RINAT NEUROSCIENCE CORP.

Inventor： Santiago Esteban FARIAS ,  Meritxell GALINDO CASAS ,  Pavel STROP

IPC: A61K47/48

CPC classification number: A61K47/6803 ,  A61K47/68 ,  A61K47/6805 ,  A61K47/6809 ,  A61K47/6817

Abstract: The present invention provides engineered polypeptide conjugates (e.g., antibody-drug-conjugates) comprising specific acyl donor glutamine-containing tags and amine donor agents. The invention also provides methods of making such engineered polypeptide conjugates using transglutaminase and methods of using thereof.

Abstract translation: 本发明提供包含特定酰基供体谷氨酰胺标签和胺供体试剂的工程改造的多肽缀合物（例如抗体 - 药物偶联物）。 本发明还提供了使用转谷氨酰胺酶制备这种工程化多肽缀合物的方法及其使用方法。

公开(公告)号：US20210162058A1

公开(公告)日：2021-06-03

申请号：US17069969

申请日：2020-10-14

Applicant: RINAT NEUROSCIENCE CORP.

Inventor： Santiago Esteban FARIAS ,  Meritxell GALINDO CASAS ,  Pavel STROP

IPC: A61K47/68

Abstract: The present invention provides engineered polypeptide conjugates (e.g., antibody-drug-conjugates) comprising specific acyl donor glutamine-containing tags and amine donor agents. The invention also provides methods of making such engineered polypeptide conjugates using transglutaminase and methods of using thereof.