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公开(公告)号：US20240009319A1
公开(公告)日：2024-01-11
申请号：US18347280
申请日：2023-07-05
IPC分类号： A61K47/68
CPC分类号： A61K47/6803 , A61K47/68 , A61K47/6817 , A61K47/6809 , A61K47/6805
摘要： The present invention provides engineered polypeptide conjugates (e.g., antibody-drug-conjugates) comprising specific acyl donor glutamine-containing tags and amine donor agents. The invention also provides methods of making such engineered polypeptide conjugates using transglutaminase and methods of using thereof.
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公开(公告)号：US20160193356A1
公开(公告)日：2016-07-07
申请号：US14908492
申请日：2014-07-30
IPC分类号： A61K47/48
CPC分类号： A61K47/6803 , A61K47/68 , A61K47/6805 , A61K47/6809 , A61K47/6817
摘要： The present invention provides engineered polypeptide conjugates (e.g., antibody-drug-conjugates) comprising specific acyl donor glutamine-containing tags and amine donor agents. The invention also provides methods of making such engineered polypeptide conjugates using transglutaminase and methods of using thereof.
摘要翻译： 本发明提供包含特定酰基供体谷氨酰胺标签和胺供体试剂的工程改造的多肽缀合物（例如抗体 - 药物偶联物）。 本发明还提供了使用转谷氨酰胺酶制备这种工程化多肽缀合物的方法及其使用方法。
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公开(公告)号：US20210162058A1
公开(公告)日：2021-06-03
申请号：US17069969
申请日：2020-10-14
IPC分类号： A61K47/68
摘要： The present invention provides engineered polypeptide conjugates (e.g., antibody-drug-conjugates) comprising specific acyl donor glutamine-containing tags and amine donor agents. The invention also provides methods of making such engineered polypeptide conjugates using transglutaminase and methods of using thereof.
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